Immunogenic cell death in cancer: concept and therapeutic implications

Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instanc...

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Autores principales: Galluzzi, Lorenzo, Kepp, Oliver, Hett, Erik, Kroemer, Guido, Marincola, Francesco M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979428/
https://www.ncbi.nlm.nih.gov/pubmed/36864446
http://dx.doi.org/10.1186/s12967-023-04017-6
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author Galluzzi, Lorenzo
Kepp, Oliver
Hett, Erik
Kroemer, Guido
Marincola, Francesco M.
author_facet Galluzzi, Lorenzo
Kepp, Oliver
Hett, Erik
Kroemer, Guido
Marincola, Francesco M.
author_sort Galluzzi, Lorenzo
collection PubMed
description Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.
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spelling pubmed-99794282023-03-03 Immunogenic cell death in cancer: concept and therapeutic implications Galluzzi, Lorenzo Kepp, Oliver Hett, Erik Kroemer, Guido Marincola, Francesco M. J Transl Med Review Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy. BioMed Central 2023-03-02 /pmc/articles/PMC9979428/ /pubmed/36864446 http://dx.doi.org/10.1186/s12967-023-04017-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Galluzzi, Lorenzo
Kepp, Oliver
Hett, Erik
Kroemer, Guido
Marincola, Francesco M.
Immunogenic cell death in cancer: concept and therapeutic implications
title Immunogenic cell death in cancer: concept and therapeutic implications
title_full Immunogenic cell death in cancer: concept and therapeutic implications
title_fullStr Immunogenic cell death in cancer: concept and therapeutic implications
title_full_unstemmed Immunogenic cell death in cancer: concept and therapeutic implications
title_short Immunogenic cell death in cancer: concept and therapeutic implications
title_sort immunogenic cell death in cancer: concept and therapeutic implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979428/
https://www.ncbi.nlm.nih.gov/pubmed/36864446
http://dx.doi.org/10.1186/s12967-023-04017-6
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