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Understanding cancer predisposition in Singapore: what's next

Knowledge of an underlying genetic predisposition to cancer allows the use of personalised prognostic, preventive and therapeutic strategies for the patient and carries clinical implications for family members. Despite great progress, we identified six challenging areas in the management of patients...

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Detalles Bibliográficos
Autores principales: Chiang, Jianbang, Shaw, Tarryn, Ngeow, Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979800/
https://www.ncbi.nlm.nih.gov/pubmed/36722515
http://dx.doi.org/10.4103/singaporemedj.SMJ-2021-468
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author Chiang, Jianbang
Shaw, Tarryn
Ngeow, Joanne
author_facet Chiang, Jianbang
Shaw, Tarryn
Ngeow, Joanne
author_sort Chiang, Jianbang
collection PubMed
description Knowledge of an underlying genetic predisposition to cancer allows the use of personalised prognostic, preventive and therapeutic strategies for the patient and carries clinical implications for family members. Despite great progress, we identified six challenging areas in the management of patients with hereditary cancer predisposition syndromes and suggest recommendations to aid in their resolution. These include the potential for finding unexpected germline variants through somatic tumour testing, optimal risk management of patients with hereditary conditions involving moderate-penetrance genes, role of polygenic risk score in an under-represented Asian population, management of variants of uncertain significance, clinical trials in patients with germline pathogenic variants and technology in genetic counselling. Addressing these barriers will aid the next step forward in precision medicine in Singapore. All stakeholders in healthcare should be empowered with genetic knowledge to fully leverage the potential of novel genomic insights and implement them to provide better care for our patients.
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spelling pubmed-99798002023-03-03 Understanding cancer predisposition in Singapore: what's next Chiang, Jianbang Shaw, Tarryn Ngeow, Joanne Singapore Med J Review Article Knowledge of an underlying genetic predisposition to cancer allows the use of personalised prognostic, preventive and therapeutic strategies for the patient and carries clinical implications for family members. Despite great progress, we identified six challenging areas in the management of patients with hereditary cancer predisposition syndromes and suggest recommendations to aid in their resolution. These include the potential for finding unexpected germline variants through somatic tumour testing, optimal risk management of patients with hereditary conditions involving moderate-penetrance genes, role of polygenic risk score in an under-represented Asian population, management of variants of uncertain significance, clinical trials in patients with germline pathogenic variants and technology in genetic counselling. Addressing these barriers will aid the next step forward in precision medicine in Singapore. All stakeholders in healthcare should be empowered with genetic knowledge to fully leverage the potential of novel genomic insights and implement them to provide better care for our patients. Wolters Kluwer - Medknow 2023-01-19 /pmc/articles/PMC9979800/ /pubmed/36722515 http://dx.doi.org/10.4103/singaporemedj.SMJ-2021-468 Text en Copyright: © 2023 Singapore Medical Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Chiang, Jianbang
Shaw, Tarryn
Ngeow, Joanne
Understanding cancer predisposition in Singapore: what's next
title Understanding cancer predisposition in Singapore: what's next
title_full Understanding cancer predisposition in Singapore: what's next
title_fullStr Understanding cancer predisposition in Singapore: what's next
title_full_unstemmed Understanding cancer predisposition in Singapore: what's next
title_short Understanding cancer predisposition in Singapore: what's next
title_sort understanding cancer predisposition in singapore: what's next
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979800/
https://www.ncbi.nlm.nih.gov/pubmed/36722515
http://dx.doi.org/10.4103/singaporemedj.SMJ-2021-468
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