Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block

Cardiac bradyarrhythmia and conduction disorder may be rare, but recurrent adverse events caused by bortezomib. Here we report a case with POEMS syndrome presenting severe heart block after bortezomib plus dexamethasone therapy. After permanent pacemaker implantation, bortezomib was restarted and ma...

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Detalles Bibliográficos
Autores principales: Nakamura, Yuichi, Itoh, Yoshihiro, Wakimoto, Naoki, Kanno, Ryu, Iida, Shinichirou, Yamamoto, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979967/
https://www.ncbi.nlm.nih.gov/pubmed/36873076
http://dx.doi.org/10.1002/ccr3.7004
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author Nakamura, Yuichi
Itoh, Yoshihiro
Wakimoto, Naoki
Kanno, Ryu
Iida, Shinichirou
Yamamoto, Keiji
author_facet Nakamura, Yuichi
Itoh, Yoshihiro
Wakimoto, Naoki
Kanno, Ryu
Iida, Shinichirou
Yamamoto, Keiji
author_sort Nakamura, Yuichi
collection PubMed
description Cardiac bradyarrhythmia and conduction disorder may be rare, but recurrent adverse events caused by bortezomib. Here we report a case with POEMS syndrome presenting severe heart block after bortezomib plus dexamethasone therapy. After permanent pacemaker implantation, bortezomib was restarted and maintained, resulting in sustained complete response for POEMS syndrome.
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spelling pubmed-99799672023-03-03 Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block Nakamura, Yuichi Itoh, Yoshihiro Wakimoto, Naoki Kanno, Ryu Iida, Shinichirou Yamamoto, Keiji Clin Case Rep Case Report Cardiac bradyarrhythmia and conduction disorder may be rare, but recurrent adverse events caused by bortezomib. Here we report a case with POEMS syndrome presenting severe heart block after bortezomib plus dexamethasone therapy. After permanent pacemaker implantation, bortezomib was restarted and maintained, resulting in sustained complete response for POEMS syndrome. John Wiley and Sons Inc. 2023-03-02 /pmc/articles/PMC9979967/ /pubmed/36873076 http://dx.doi.org/10.1002/ccr3.7004 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nakamura, Yuichi
Itoh, Yoshihiro
Wakimoto, Naoki
Kanno, Ryu
Iida, Shinichirou
Yamamoto, Keiji
Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block
title Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block
title_full Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block
title_fullStr Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block
title_full_unstemmed Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block
title_short Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block
title_sort successful treatment with bortezomib for poems syndrome, overcoming complicated severe heart block
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979967/
https://www.ncbi.nlm.nih.gov/pubmed/36873076
http://dx.doi.org/10.1002/ccr3.7004
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