MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

Increased mitochondrial function may render some cancers vulnerable to mitochondrial inhibitors. Since mitochondrial function is regulated partly by mitochondrial DNA copy number (mtDNAcn), accurate measurements of mtDNAcn could help reveal which cancers are driven by increased mitochondrial functio...

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Detalles Bibliográficos
Autores principales: Chen, Jiayu, Zheng, Qizhi, Hicks, Jessica L., Trabzonlu, Levent, Ozbek, Busra, Jones, Tracy, Vaghasia, Ajay, Larman, Tatianna C., Wang, Rulin, Markowski, Mark C., Denmeade, Sam R., Pienta, Kenneth J., Hruban, Ralph H., Antonarakis, Emmanuel S., Gupta, Anuj, Dang, Chi V, Yegnasubramanian, Srinivasan, De Marzo, Angelo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979994/
https://www.ncbi.nlm.nih.gov/pubmed/36865273
http://dx.doi.org/10.1101/2023.02.20.529259

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