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cGLRs are a diverse family of pattern recognition receptors in animal innate immunity

cGAS (cyclic GMP-AMP synthase) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2′3′-cGAMP that activates the protein STING and downstream immunity. Here we discover cGAS-like receptors (cGLRs) constitute a major fa...

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Detalles Bibliográficos
Autores principales:	Li, Yao, Slavik, Kailey M., Morehouse, Benjamin R., de Oliveira Mann, Carina C., Mears, Kepler, Liu, Jingjing, Kashin, Dmitry, Schwede, Frank, Kranzusch, Philip J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980059/ https://www.ncbi.nlm.nih.gov/pubmed/36865129 http://dx.doi.org/10.1101/2023.02.22.529553

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