The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts

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Women experience osteoporosis at higher rates than men. Aside from hormones, the mechanisms driving sex-dependent bone mass regulation are not well-understood. Here, we demonstrate that the X-linked H3K4me2/3 demethylase KDM5C regulates sex-specific bone mass. Loss of KDM5C in hematopoietic stem cel...

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Detalles Bibliográficos
Autores principales: Liu, Huadie, Zhai, Lukai, Liu, Ye, Lu, Di, VanderArk, Alexandra, Yang, Tao, Krawczyk, Connie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980061/
https://www.ncbi.nlm.nih.gov/pubmed/36865269
http://dx.doi.org/10.1101/2023.02.23.529728

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