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Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes
Intracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation is often compromised by the adverse tissue responses to the indwelling electrodes. Here we engineer ul...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980065/ https://www.ncbi.nlm.nih.gov/pubmed/36865195 http://dx.doi.org/10.1101/2023.02.20.529295 |
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author | Lycke, Roy Kim, Robin Zolotavin, Pavlo Montes, Jon Sun, Yingchu Koszeghy, Aron Altun, Esra Noble, Brian Yin, Rongkang He, Fei Totah, Nelson Xie, Chong Luan, Lan |
author_facet | Lycke, Roy Kim, Robin Zolotavin, Pavlo Montes, Jon Sun, Yingchu Koszeghy, Aron Altun, Esra Noble, Brian Yin, Rongkang He, Fei Totah, Nelson Xie, Chong Luan, Lan |
author_sort | Lycke, Roy |
collection | PubMed |
description | Intracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation is often compromised by the adverse tissue responses to the indwelling electrodes. Here we engineer ultraflexible stim-Nanoelectronic Threads (StimNETs) and demonstrate low activation threshold, high resolution, and chronically stable ICMS in awake, behaving mouse models. In vivo two-photon imaging reveals that StimNETs remain seamlessly integrated with the nervous tissue throughout chronic stimulation periods and elicit stable, focal neuronal activation at low currents of 2 μA. Importantly, StimNETs evoke longitudinally stable behavioral responses for over eight months at markedly low charge injection of 0.25 nC/phase. Quantified histological analysis show that chronic ICMS by StimNETs induce no neuronal degeneration or glial scarring. These results suggest that tissue-integrated electrodes provide a path for robust, long-lasting, spatially-selective neuromodulation at low currents which lessen risks of tissue damage or exacerbation of off-target side-effects. |
format | Online Article Text |
id | pubmed-9980065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-99800652023-03-03 Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes Lycke, Roy Kim, Robin Zolotavin, Pavlo Montes, Jon Sun, Yingchu Koszeghy, Aron Altun, Esra Noble, Brian Yin, Rongkang He, Fei Totah, Nelson Xie, Chong Luan, Lan bioRxiv Article Intracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation is often compromised by the adverse tissue responses to the indwelling electrodes. Here we engineer ultraflexible stim-Nanoelectronic Threads (StimNETs) and demonstrate low activation threshold, high resolution, and chronically stable ICMS in awake, behaving mouse models. In vivo two-photon imaging reveals that StimNETs remain seamlessly integrated with the nervous tissue throughout chronic stimulation periods and elicit stable, focal neuronal activation at low currents of 2 μA. Importantly, StimNETs evoke longitudinally stable behavioral responses for over eight months at markedly low charge injection of 0.25 nC/phase. Quantified histological analysis show that chronic ICMS by StimNETs induce no neuronal degeneration or glial scarring. These results suggest that tissue-integrated electrodes provide a path for robust, long-lasting, spatially-selective neuromodulation at low currents which lessen risks of tissue damage or exacerbation of off-target side-effects. Cold Spring Harbor Laboratory 2023-02-21 /pmc/articles/PMC9980065/ /pubmed/36865195 http://dx.doi.org/10.1101/2023.02.20.529295 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Lycke, Roy Kim, Robin Zolotavin, Pavlo Montes, Jon Sun, Yingchu Koszeghy, Aron Altun, Esra Noble, Brian Yin, Rongkang He, Fei Totah, Nelson Xie, Chong Luan, Lan Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes |
title | Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes |
title_full | Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes |
title_fullStr | Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes |
title_full_unstemmed | Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes |
title_short | Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes |
title_sort | low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980065/ https://www.ncbi.nlm.nih.gov/pubmed/36865195 http://dx.doi.org/10.1101/2023.02.20.529295 |
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