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Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes

Adoptive immunotherapy with Tregs is a promising approach for prevention or treatment of type 1 diabetes. Islet antigen-specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical application. To generate Tregs that recognize islet ant...

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Detalles Bibliográficos
Autores principales:	Spanier, Justin A., Fung, Vivian, Wardell, Christine M., Alkhatib, Mohannad H., Chen, Yixin, Swanson, Linnea A., Dwyer, Alexander J., Weno, Matthew E., Silva, Nubia, Mitchell, Jason S., Orban, Paul C., Mojibian, Majid, Verchere, C. Bruce, Fife, Brian T., Levings, Megan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980092/ https://www.ncbi.nlm.nih.gov/pubmed/36865264 http://dx.doi.org/10.1101/2023.02.23.529737

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