Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease

The SARS-CoV-2 main protease (M(pro)) is critical for the production of functional viral proteins during infection and, like many viral proteases, can also target host proteins to subvert their cellular functions. Here, we show that the human tRNA methyltransferase TRMT1 can be recognized and cleave...

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Detalles Bibliográficos
Autores principales: D′Oliviera, Angel, Dai, Xuhang, Mottaghinia, Saba, Geissler, Evan P., Etienne, Lucie, Zhang, Yingkai, Mugridge, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980103/
https://www.ncbi.nlm.nih.gov/pubmed/36865253
http://dx.doi.org/10.1101/2023.02.20.529306

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