Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models

Euchromatic histone lysine methyltransferases 1 and 2 (EHMT1/2), which catalyze demethylation of histone H3 lysine 9 (H3K9me2), contribute to tumorigenesis and therapy resistance through unknown mechanisms of action. In ovarian cancer, EHMT1/2 and H3K9me2 are directly linked to acquired resistance t...

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Detalles Bibliográficos
Autores principales: Nguyen, Lily L., Watson, Zachary L., Ortega, Raquel, Woodruff, Elizabeth R., Jordan, Kimberly R., Iwanaga, Ritsuko, Yamamoto, Tomomi M., Bailey, Courtney A., Jeong, Abigail D., Guntupalli, Saketh R., Behbakht, Kian, Gbaja, Veronica, Arnoult, Nausica, Chuong, Edward B., Bitler, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980116/
https://www.ncbi.nlm.nih.gov/pubmed/36865165
http://dx.doi.org/10.1101/2023.02.23.529773

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