Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons

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Progranulin (PGRN) is a lysosomal protein implicated in various neurodegenerative diseases. Over 70 mutations discovered in the GRN gene all result in reduced expression of PGRN protein. However, the detailed molecular function of PGRN within lysosomes and the impact of PGRN deficiency on lysosomal...

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Detalles Bibliográficos
Autores principales: Hasan, Saadia, Fernandopulle, Michael S., Humble, Stewart W., Frankenfield, Ashley M., Li, Haorong, Prestil, Ryan, Johnson, Kory R., Ryan, Brent J., Wade-Martins, Richard, Ward, Michael E., Hao, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980118/
https://www.ncbi.nlm.nih.gov/pubmed/36865171
http://dx.doi.org/10.1101/2023.02.24.529955
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