O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations

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The neurofilament (NF) cytoskeleton is critical for neuronal morphology and function. In particular, the neurofilament-light (NF-L) subunit is required for NF assembly in vivo and is mutated in subtypes of Charcot-Marie-Tooth (CMT) disease. NFs are highly dynamic, and the regulation of NF assembly s...

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Autores principales: Huynh, Duc T., Hu, Jimin, Schneider, Jordan R., Tsolova, Kalina N., Soderblom, Erik J., Watson, Abigail J., Chi, Jen-Tsan, Evans, Chantell S., Boyce, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980138/
https://www.ncbi.nlm.nih.gov/pubmed/36865196
http://dx.doi.org/10.1101/2023.02.22.529563
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