Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells, little is known of the metabolic alterations within these cells that fuel invasion. We integrated spatially addressable hydrogel biomaterial platforms, patient site-directed biopsies, and multi-omics analys...

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Detalles Bibliográficos
Autores principales: Garcia, Joseph H., Akins, Erin A., Jain, Saket, Wolf, Kayla J., Zhang, Jason, Choudhary, Nikita, Lad, Meeki, Shukla, Poojan, Gill, Sabraj, Carson, Will, Carette, Luis, Zheng, Allison, Kumar, Sanjay, Aghi, Manish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980149/
https://www.ncbi.nlm.nih.gov/pubmed/36865128
http://dx.doi.org/10.1101/2023.02.23.529575

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