13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue

Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of (13)C, (1...

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Autores principales: Barclay, Alexander M., Dhavale, Dhruva D., Borcik, Collin G., Milchberg, Moses H., Kotzbauer, Paul T., Rienstra, Chad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980205/
https://www.ncbi.nlm.nih.gov/pubmed/36865115
http://dx.doi.org/10.21203/rs.3.rs-2460685/v1
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author Barclay, Alexander M.
Dhavale, Dhruva D.
Borcik, Collin G.
Milchberg, Moses H.
Kotzbauer, Paul T.
Rienstra, Chad M.
author_facet Barclay, Alexander M.
Dhavale, Dhruva D.
Borcik, Collin G.
Milchberg, Moses H.
Kotzbauer, Paul T.
Rienstra, Chad M.
author_sort Barclay, Alexander M.
collection PubMed
description Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of (13)C, (15)N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.
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spelling pubmed-99802052023-03-03 13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue Barclay, Alexander M. Dhavale, Dhruva D. Borcik, Collin G. Milchberg, Moses H. Kotzbauer, Paul T. Rienstra, Chad M. Res Sq Article Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of (13)C, (15)N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia. American Journal Experts 2023-02-24 /pmc/articles/PMC9980205/ /pubmed/36865115 http://dx.doi.org/10.21203/rs.3.rs-2460685/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Barclay, Alexander M.
Dhavale, Dhruva D.
Borcik, Collin G.
Milchberg, Moses H.
Kotzbauer, Paul T.
Rienstra, Chad M.
13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
title 13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
title_full 13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
title_fullStr 13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
title_full_unstemmed 13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
title_short 13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
title_sort 13c and 15n resonance assignments of alpha synuclein fibrils amplified from lewy body dementia tissue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980205/
https://www.ncbi.nlm.nih.gov/pubmed/36865115
http://dx.doi.org/10.21203/rs.3.rs-2460685/v1
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