Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases

Polygenic risk scores (PRS) are an emerging tool to predict the clinical phenotypes and outcomes of individuals. Validation and transferability of existing PRS across independent datasets and diverse ancestries are limited, which hinders the practical utility and exacerbates health disparities. We p...

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Detalles Bibliográficos
Autores principales: Truong, Buu, Hull, Leland E., Ruan, Yunfeng, Huang, Qin Qin, Hornsby, Whitney, Martin, Hilary, van Heel, David A., Wang, Ying, Martin, Alicia R., Lee, S. Hong, Natarajan, Pradeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980241/
https://www.ncbi.nlm.nih.gov/pubmed/36865265
http://dx.doi.org/10.1101/2023.02.21.23286110

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