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Registry randomised trials: a methodological perspective
Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a reduced cost compared with traditional randomised...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980340/ https://www.ncbi.nlm.nih.gov/pubmed/36858472 http://dx.doi.org/10.1136/bmjopen-2022-068057 |
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author | Doherty, Dorota A Tong, Steven Y C Reilly, Jennifer Shrapnel, Jane McDonald, Stephen Ahern, Susannah Harris, Ian Tam, Charmaine S Brennan, Angela L Hodgson, Carol Wilcox, Leonie Balagurunathan, Anitha Butcher, Belinda E Reid, Christopher M |
author_facet | Doherty, Dorota A Tong, Steven Y C Reilly, Jennifer Shrapnel, Jane McDonald, Stephen Ahern, Susannah Harris, Ian Tam, Charmaine S Brennan, Angela L Hodgson, Carol Wilcox, Leonie Balagurunathan, Anitha Butcher, Belinda E Reid, Christopher M |
author_sort | Doherty, Dorota A |
collection | PubMed |
description | Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a reduced cost compared with traditional randomised controlled trials. RRCTs can take a number of forms in addition to the traditional individual-level randomised trial, including parallel group trials, platform or adaptive trials, cluster randomised trials and cluster randomised stepped-wedge trials. From an implementation perspective, initially it is advantageous to embed RRCT into well-established registries as these have typically already overcome any issues with end point validation and adjudication. With advances in data linkage and data quality, RRCTs can play an important role in answering clinical questions in a pragmatic, cost-effective way. |
format | Online Article Text |
id | pubmed-9980340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-99803402023-03-03 Registry randomised trials: a methodological perspective Doherty, Dorota A Tong, Steven Y C Reilly, Jennifer Shrapnel, Jane McDonald, Stephen Ahern, Susannah Harris, Ian Tam, Charmaine S Brennan, Angela L Hodgson, Carol Wilcox, Leonie Balagurunathan, Anitha Butcher, Belinda E Reid, Christopher M BMJ Open Research Methods Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a reduced cost compared with traditional randomised controlled trials. RRCTs can take a number of forms in addition to the traditional individual-level randomised trial, including parallel group trials, platform or adaptive trials, cluster randomised trials and cluster randomised stepped-wedge trials. From an implementation perspective, initially it is advantageous to embed RRCT into well-established registries as these have typically already overcome any issues with end point validation and adjudication. With advances in data linkage and data quality, RRCTs can play an important role in answering clinical questions in a pragmatic, cost-effective way. BMJ Publishing Group 2023-03-01 /pmc/articles/PMC9980340/ /pubmed/36858472 http://dx.doi.org/10.1136/bmjopen-2022-068057 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Research Methods Doherty, Dorota A Tong, Steven Y C Reilly, Jennifer Shrapnel, Jane McDonald, Stephen Ahern, Susannah Harris, Ian Tam, Charmaine S Brennan, Angela L Hodgson, Carol Wilcox, Leonie Balagurunathan, Anitha Butcher, Belinda E Reid, Christopher M Registry randomised trials: a methodological perspective |
title | Registry randomised trials: a methodological perspective |
title_full | Registry randomised trials: a methodological perspective |
title_fullStr | Registry randomised trials: a methodological perspective |
title_full_unstemmed | Registry randomised trials: a methodological perspective |
title_short | Registry randomised trials: a methodological perspective |
title_sort | registry randomised trials: a methodological perspective |
topic | Research Methods |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980340/ https://www.ncbi.nlm.nih.gov/pubmed/36858472 http://dx.doi.org/10.1136/bmjopen-2022-068057 |
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