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Registry randomised trials: a methodological perspective

Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a reduced cost compared with traditional randomised...

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Autores principales: Doherty, Dorota A, Tong, Steven Y C, Reilly, Jennifer, Shrapnel, Jane, McDonald, Stephen, Ahern, Susannah, Harris, Ian, Tam, Charmaine S, Brennan, Angela L, Hodgson, Carol, Wilcox, Leonie, Balagurunathan, Anitha, Butcher, Belinda E, Reid, Christopher M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980340/
https://www.ncbi.nlm.nih.gov/pubmed/36858472
http://dx.doi.org/10.1136/bmjopen-2022-068057
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author Doherty, Dorota A
Tong, Steven Y C
Reilly, Jennifer
Shrapnel, Jane
McDonald, Stephen
Ahern, Susannah
Harris, Ian
Tam, Charmaine S
Brennan, Angela L
Hodgson, Carol
Wilcox, Leonie
Balagurunathan, Anitha
Butcher, Belinda E
Reid, Christopher M
author_facet Doherty, Dorota A
Tong, Steven Y C
Reilly, Jennifer
Shrapnel, Jane
McDonald, Stephen
Ahern, Susannah
Harris, Ian
Tam, Charmaine S
Brennan, Angela L
Hodgson, Carol
Wilcox, Leonie
Balagurunathan, Anitha
Butcher, Belinda E
Reid, Christopher M
author_sort Doherty, Dorota A
collection PubMed
description Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a reduced cost compared with traditional randomised controlled trials. RRCTs can take a number of forms in addition to the traditional individual-level randomised trial, including parallel group trials, platform or adaptive trials, cluster randomised trials and cluster randomised stepped-wedge trials. From an implementation perspective, initially it is advantageous to embed RRCT into well-established registries as these have typically already overcome any issues with end point validation and adjudication. With advances in data linkage and data quality, RRCTs can play an important role in answering clinical questions in a pragmatic, cost-effective way.
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spelling pubmed-99803402023-03-03 Registry randomised trials: a methodological perspective Doherty, Dorota A Tong, Steven Y C Reilly, Jennifer Shrapnel, Jane McDonald, Stephen Ahern, Susannah Harris, Ian Tam, Charmaine S Brennan, Angela L Hodgson, Carol Wilcox, Leonie Balagurunathan, Anitha Butcher, Belinda E Reid, Christopher M BMJ Open Research Methods Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a reduced cost compared with traditional randomised controlled trials. RRCTs can take a number of forms in addition to the traditional individual-level randomised trial, including parallel group trials, platform or adaptive trials, cluster randomised trials and cluster randomised stepped-wedge trials. From an implementation perspective, initially it is advantageous to embed RRCT into well-established registries as these have typically already overcome any issues with end point validation and adjudication. With advances in data linkage and data quality, RRCTs can play an important role in answering clinical questions in a pragmatic, cost-effective way. BMJ Publishing Group 2023-03-01 /pmc/articles/PMC9980340/ /pubmed/36858472 http://dx.doi.org/10.1136/bmjopen-2022-068057 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Research Methods
Doherty, Dorota A
Tong, Steven Y C
Reilly, Jennifer
Shrapnel, Jane
McDonald, Stephen
Ahern, Susannah
Harris, Ian
Tam, Charmaine S
Brennan, Angela L
Hodgson, Carol
Wilcox, Leonie
Balagurunathan, Anitha
Butcher, Belinda E
Reid, Christopher M
Registry randomised trials: a methodological perspective
title Registry randomised trials: a methodological perspective
title_full Registry randomised trials: a methodological perspective
title_fullStr Registry randomised trials: a methodological perspective
title_full_unstemmed Registry randomised trials: a methodological perspective
title_short Registry randomised trials: a methodological perspective
title_sort registry randomised trials: a methodological perspective
topic Research Methods
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980340/
https://www.ncbi.nlm.nih.gov/pubmed/36858472
http://dx.doi.org/10.1136/bmjopen-2022-068057
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