The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development

The coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein is a structural protein involved in viral replication and assembly....

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Autores principales: Yu, Haiyun, Guan, Fei, Miller, Heather, Lei, Jiahui, Liu, Chaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Coronaviruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980416/
https://www.ncbi.nlm.nih.gov/pubmed/36583642
http://dx.doi.org/10.1080/22221751.2022.2164219
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author Yu, Haiyun
Guan, Fei
Miller, Heather
Lei, Jiahui
Liu, Chaohong
author_facet Yu, Haiyun
Guan, Fei
Miller, Heather
Lei, Jiahui
Liu, Chaohong
author_sort Yu, Haiyun
collection PubMed
description The coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein is a structural protein involved in viral replication and assembly. There is accumulating evidence indicating that the nucleocapsid protein is multi-functional, playing a key role in the pathogenesis of COVID-19 and antiviral immunity against SARS-CoV-2. Here, we summarize its potential application in the prevention of COVID-19, which is based on its role in inflammation, cell death, antiviral innate immunity, and antiviral adaptive immunity.
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spelling pubmed-99804162023-03-03 The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development Yu, Haiyun Guan, Fei Miller, Heather Lei, Jiahui Liu, Chaohong Emerg Microbes Infect Coronaviruses The coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein is a structural protein involved in viral replication and assembly. There is accumulating evidence indicating that the nucleocapsid protein is multi-functional, playing a key role in the pathogenesis of COVID-19 and antiviral immunity against SARS-CoV-2. Here, we summarize its potential application in the prevention of COVID-19, which is based on its role in inflammation, cell death, antiviral innate immunity, and antiviral adaptive immunity. Taylor & Francis 2023-03-01 /pmc/articles/PMC9980416/ /pubmed/36583642 http://dx.doi.org/10.1080/22221751.2022.2164219 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Coronaviruses
Yu, Haiyun
Guan, Fei
Miller, Heather
Lei, Jiahui
Liu, Chaohong
The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development
title The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development
title_full The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development
title_fullStr The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development
title_full_unstemmed The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development
title_short The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development
title_sort role of sars-cov-2 nucleocapsid protein in antiviral immunity and vaccine development
topic Coronaviruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980416/
https://www.ncbi.nlm.nih.gov/pubmed/36583642
http://dx.doi.org/10.1080/22221751.2022.2164219
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