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Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants
Migration from one location to another often comes with a change in environmental conditions. Here, we analysed features of DNA methylation in young, adult British-Bangladeshi women who experienced different environments during their childhoods: a) migrants, who grew up in Bangladesh with exposure t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980690/ https://www.ncbi.nlm.nih.gov/pubmed/36495138 http://dx.doi.org/10.1080/15592294.2022.2153511 |
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author | Stöger, Reinhard Choi, Minseung Begum, Khurshida Leeman, Gregory Emes, Richard D. Melamed, Philippa Bentley, Gillian R. |
author_facet | Stöger, Reinhard Choi, Minseung Begum, Khurshida Leeman, Gregory Emes, Richard D. Melamed, Philippa Bentley, Gillian R. |
author_sort | Stöger, Reinhard |
collection | PubMed |
description | Migration from one location to another often comes with a change in environmental conditions. Here, we analysed features of DNA methylation in young, adult British-Bangladeshi women who experienced different environments during their childhoods: a) migrants, who grew up in Bangladesh with exposure to comparatively higher pathogen loads and poorer health care, and b) second-generation British-Bangladeshis, born to Bangladeshi parents, who grew up in the UK. We used buccal DNA to estimate DNA methylation-based age (DNAm age) from 14 migrants and 11 second-generation migrants, aged 18–35 years. ‘AgeAccel,’ a measure of DNAm age, independent of chronological age, showed that the group of women who spent their childhood in Bangladesh had higher AgeAccel (P = 0.028), compared to their UK peers. Since epigenetic clocks have been proposed to be associated with maintenance processes of epigenetic systems, we evaluated the preference for concordant DNA methylation at the luteinizing hormone/choriogonadotropin receptor (LHCGR/LHR) locus, which harbours one of the CpGs contributing to Horvath’s epigenetic clock. Measurements on both strands of individual, double-stranded DNA molecules indicate higher stability of DNA methylation states at this LHCGR/LHR locus in samples of women who grew up in Bangladesh. Together, our two independent analytical approaches imply that childhood environments may induce subtle changes that are detectable long after exposure occurred, which might reflect altered activity of the epigenetic maintenance system or a difference in the proportion of cell types in buccal tissue. This exploratory work supports our earlier findings that adverse childhood environments lead to phenotypic life history trade-offs. |
format | Online Article Text |
id | pubmed-9980690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-99806902023-03-03 Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants Stöger, Reinhard Choi, Minseung Begum, Khurshida Leeman, Gregory Emes, Richard D. Melamed, Philippa Bentley, Gillian R. Epigenetics Research Paper Migration from one location to another often comes with a change in environmental conditions. Here, we analysed features of DNA methylation in young, adult British-Bangladeshi women who experienced different environments during their childhoods: a) migrants, who grew up in Bangladesh with exposure to comparatively higher pathogen loads and poorer health care, and b) second-generation British-Bangladeshis, born to Bangladeshi parents, who grew up in the UK. We used buccal DNA to estimate DNA methylation-based age (DNAm age) from 14 migrants and 11 second-generation migrants, aged 18–35 years. ‘AgeAccel,’ a measure of DNAm age, independent of chronological age, showed that the group of women who spent their childhood in Bangladesh had higher AgeAccel (P = 0.028), compared to their UK peers. Since epigenetic clocks have been proposed to be associated with maintenance processes of epigenetic systems, we evaluated the preference for concordant DNA methylation at the luteinizing hormone/choriogonadotropin receptor (LHCGR/LHR) locus, which harbours one of the CpGs contributing to Horvath’s epigenetic clock. Measurements on both strands of individual, double-stranded DNA molecules indicate higher stability of DNA methylation states at this LHCGR/LHR locus in samples of women who grew up in Bangladesh. Together, our two independent analytical approaches imply that childhood environments may induce subtle changes that are detectable long after exposure occurred, which might reflect altered activity of the epigenetic maintenance system or a difference in the proportion of cell types in buccal tissue. This exploratory work supports our earlier findings that adverse childhood environments lead to phenotypic life history trade-offs. Taylor & Francis 2022-12-10 /pmc/articles/PMC9980690/ /pubmed/36495138 http://dx.doi.org/10.1080/15592294.2022.2153511 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Stöger, Reinhard Choi, Minseung Begum, Khurshida Leeman, Gregory Emes, Richard D. Melamed, Philippa Bentley, Gillian R. Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants |
title | Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants |
title_full | Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants |
title_fullStr | Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants |
title_full_unstemmed | Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants |
title_short | Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants |
title_sort | childhood environment influences epigenetic age and methylation concordance of a cpg clock locus in british-bangladeshi migrants |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980690/ https://www.ncbi.nlm.nih.gov/pubmed/36495138 http://dx.doi.org/10.1080/15592294.2022.2153511 |
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