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TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability

The challenge of rapid macromolecular synthesis enforces the energy-hungry cancer cell mitochondria to switch their metabolic phenotypes, accomplished by activation of oncogenic tyrosine kinases. Precisely how kinase activity is directly exploited by cancer cell mitochondria to meet high-energy dema...

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Detalles Bibliográficos
Autores principales:	Chouhan, Surbhi, Sawant, Mithila, Weimholt, Cody, Luo, Jingqin, Sprung, Robert W., Terrado, Mailyn, Mueller, David M., Earp, H. Shelton, Mahajan, Nupam P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper – Translational
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980697/ https://www.ncbi.nlm.nih.gov/pubmed/35895804 http://dx.doi.org/10.1080/15548627.2022.2103961

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