Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study

The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was cal...

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Detalles Bibliográficos
Autores principales: Thomsen, Martin Munthe, Munthe-Fog, Lea, Trier Petersen, Pelle, Hillig, Thore, Friis-Hansen, Lennart Jan, Roed, Casper, Harboe, Zitta Barrella, Brandt, Christian Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980753/
https://www.ncbi.nlm.nih.gov/pubmed/36862691
http://dx.doi.org/10.1371/journal.pone.0282004
Descripción
Sumario:The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.

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