Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study

The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was cal...

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Autores principales: Thomsen, Martin Munthe, Munthe-Fog, Lea, Trier Petersen, Pelle, Hillig, Thore, Friis-Hansen, Lennart Jan, Roed, Casper, Harboe, Zitta Barrella, Brandt, Christian Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980753/
https://www.ncbi.nlm.nih.gov/pubmed/36862691
http://dx.doi.org/10.1371/journal.pone.0282004
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author Thomsen, Martin Munthe
Munthe-Fog, Lea
Trier Petersen, Pelle
Hillig, Thore
Friis-Hansen, Lennart Jan
Roed, Casper
Harboe, Zitta Barrella
Brandt, Christian Thomas
author_facet Thomsen, Martin Munthe
Munthe-Fog, Lea
Trier Petersen, Pelle
Hillig, Thore
Friis-Hansen, Lennart Jan
Roed, Casper
Harboe, Zitta Barrella
Brandt, Christian Thomas
author_sort Thomsen, Martin Munthe
collection PubMed
description The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.
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spelling pubmed-99807532023-03-03 Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study Thomsen, Martin Munthe Munthe-Fog, Lea Trier Petersen, Pelle Hillig, Thore Friis-Hansen, Lennart Jan Roed, Casper Harboe, Zitta Barrella Brandt, Christian Thomas PLoS One Research Article The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found. Public Library of Science 2023-03-02 /pmc/articles/PMC9980753/ /pubmed/36862691 http://dx.doi.org/10.1371/journal.pone.0282004 Text en © 2023 Thomsen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Thomsen, Martin Munthe
Munthe-Fog, Lea
Trier Petersen, Pelle
Hillig, Thore
Friis-Hansen, Lennart Jan
Roed, Casper
Harboe, Zitta Barrella
Brandt, Christian Thomas
Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study
title Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study
title_full Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study
title_fullStr Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study
title_full_unstemmed Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study
title_short Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study
title_sort pentraxin 3 in the cerebrospinal fluid during central nervous system infections: a retrospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980753/
https://www.ncbi.nlm.nih.gov/pubmed/36862691
http://dx.doi.org/10.1371/journal.pone.0282004
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