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Imaging breast malignancies with the Twente Photoacoustic Mammoscope 2
Clinical measurements on breast cancer patients were performed with a three-dimensional tomographic photoacoustic prototype imager (PAM 2). Patients with a suspicious lesion, visiting the center for breast care of a local hospital, were included in the study. The acquired photoacoustic images were c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980787/ https://www.ncbi.nlm.nih.gov/pubmed/36862628 http://dx.doi.org/10.1371/journal.pone.0281434 |
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author | Schoustra, S. M. De Santi, B. op ’t Root, T. J. P. M. Klazen, C. A. H. van der Schaaf, M. Veltman, J. Steenbergen, W. Manohar, S. |
author_facet | Schoustra, S. M. De Santi, B. op ’t Root, T. J. P. M. Klazen, C. A. H. van der Schaaf, M. Veltman, J. Steenbergen, W. Manohar, S. |
author_sort | Schoustra, S. M. |
collection | PubMed |
description | Clinical measurements on breast cancer patients were performed with a three-dimensional tomographic photoacoustic prototype imager (PAM 2). Patients with a suspicious lesion, visiting the center for breast care of a local hospital, were included in the study. The acquired photoacoustic images were compared to conventional clinical images. Of 30 scanned patients, 19 were diagnosed with one or more malignancies, of which a subset of four patients was selected for detailed analysis. Reconstructed images were processed to enhance image quality and the visibility of blood vessels. Processed photoacoustic images were compared to contrast-enhanced magnetic resonance images where available, which aided in localizing the expected tumoral region. In two cases, spotty high-intensity photoacoustic signals could be seen in the tumoral region, attributable to the tumor. One of these cases also displayed a relatively high image entropy at the tumor site, likely related to the chaotic vascular networks associated with malignancies. For the other two cases, it was not possible to identify features indicative of malignancy, because of limitations in the illumination scheme and difficulties in locating the region of interest in the photoacoustic image. |
format | Online Article Text |
id | pubmed-9980787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-99807872023-03-03 Imaging breast malignancies with the Twente Photoacoustic Mammoscope 2 Schoustra, S. M. De Santi, B. op ’t Root, T. J. P. M. Klazen, C. A. H. van der Schaaf, M. Veltman, J. Steenbergen, W. Manohar, S. PLoS One Research Article Clinical measurements on breast cancer patients were performed with a three-dimensional tomographic photoacoustic prototype imager (PAM 2). Patients with a suspicious lesion, visiting the center for breast care of a local hospital, were included in the study. The acquired photoacoustic images were compared to conventional clinical images. Of 30 scanned patients, 19 were diagnosed with one or more malignancies, of which a subset of four patients was selected for detailed analysis. Reconstructed images were processed to enhance image quality and the visibility of blood vessels. Processed photoacoustic images were compared to contrast-enhanced magnetic resonance images where available, which aided in localizing the expected tumoral region. In two cases, spotty high-intensity photoacoustic signals could be seen in the tumoral region, attributable to the tumor. One of these cases also displayed a relatively high image entropy at the tumor site, likely related to the chaotic vascular networks associated with malignancies. For the other two cases, it was not possible to identify features indicative of malignancy, because of limitations in the illumination scheme and difficulties in locating the region of interest in the photoacoustic image. Public Library of Science 2023-03-02 /pmc/articles/PMC9980787/ /pubmed/36862628 http://dx.doi.org/10.1371/journal.pone.0281434 Text en © 2023 Schoustra et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Schoustra, S. M. De Santi, B. op ’t Root, T. J. P. M. Klazen, C. A. H. van der Schaaf, M. Veltman, J. Steenbergen, W. Manohar, S. Imaging breast malignancies with the Twente Photoacoustic Mammoscope 2 |
title | Imaging breast malignancies with the Twente Photoacoustic Mammoscope 2 |
title_full | Imaging breast malignancies with the Twente Photoacoustic Mammoscope 2 |
title_fullStr | Imaging breast malignancies with the Twente Photoacoustic Mammoscope 2 |
title_full_unstemmed | Imaging breast malignancies with the Twente Photoacoustic Mammoscope 2 |
title_short | Imaging breast malignancies with the Twente Photoacoustic Mammoscope 2 |
title_sort | imaging breast malignancies with the twente photoacoustic mammoscope 2 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980787/ https://www.ncbi.nlm.nih.gov/pubmed/36862628 http://dx.doi.org/10.1371/journal.pone.0281434 |
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