The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models

The catalytic enzymes tankyrase 1 and 2 (TNKS1/2) alter protein turnover by poly-ADP-ribosylating target proteins, which earmark them for degradation by the ubiquitin–proteasomal system. Prominent targets of the catalytic activity of TNKS1/2 include AXIN proteins, resulting in TNKS1/2 being attracti...

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Detalles Bibliográficos
Autores principales: Brinch, Shoshy A., Amundsen-Isaksen, Enya, Espada, Sandra, Hammarström, Clara, Aizenshtadt, Aleksandra, Olsen, Petter A., Holmen, Lone, Høyem, Merete, Scholz, Hanne, Grødeland, Gunnveig, Sowa, Sven T., Galera-Prat, Albert, Lehtiö, Lari, Meerts, Ilonka A.T.M., Leenders, Ruben G.G., Wegert, Anita, Krauss, Stefan, Waaler, Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981206/
https://www.ncbi.nlm.nih.gov/pubmed/36873622
http://dx.doi.org/10.1158/2767-9764.CRC-22-0027

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