Rasburicase-Induced Falsely Low Measurement of Uric Acid in Tumor Lysis Syndrome: A Report of Two Cases

Rasburicase, a recombinant urate-oxidase enzyme, can significantly catalyze the oxidation of uric acid to allantoin. It was approved by the US Food and Drug Administration (FDA) to control blood uric acid levels in both pediatric and adult patients especially those with tumor lysis syndrome. It is q...

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Detalles Bibliográficos
Autores principales: Yu, Lian, Xie, Yinjing, Ma, Jiangtao, Li, Guoqiang, Yuan, Xiaopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Medical Education
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981216/
https://www.ncbi.nlm.nih.gov/pubmed/36874663
http://dx.doi.org/10.7759/cureus.34435
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author Yu, Lian
Xie, Yinjing
Ma, Jiangtao
Li, Guoqiang
Yuan, Xiaopeng
author_facet Yu, Lian
Xie, Yinjing
Ma, Jiangtao
Li, Guoqiang
Yuan, Xiaopeng
author_sort Yu, Lian
collection PubMed
description Rasburicase, a recombinant urate-oxidase enzyme, can significantly catalyze the oxidation of uric acid to allantoin. It was approved by the US Food and Drug Administration (FDA) to control blood uric acid levels in both pediatric and adult patients especially those with tumor lysis syndrome. It is quite important to realize that rasburicase can continue to be effective ex vivo and cause falsely low results if the blood sample is not contained and transported in ice water immediately. We presented two cases of falsely low measurement of blood uric acid caused by rasburicase and elaborated the proper method for collecting and transporting blood samples from patients using rasburicase.
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spelling pubmed-99812162023-03-03 Rasburicase-Induced Falsely Low Measurement of Uric Acid in Tumor Lysis Syndrome: A Report of Two Cases Yu, Lian Xie, Yinjing Ma, Jiangtao Li, Guoqiang Yuan, Xiaopeng Cureus Medical Education Rasburicase, a recombinant urate-oxidase enzyme, can significantly catalyze the oxidation of uric acid to allantoin. It was approved by the US Food and Drug Administration (FDA) to control blood uric acid levels in both pediatric and adult patients especially those with tumor lysis syndrome. It is quite important to realize that rasburicase can continue to be effective ex vivo and cause falsely low results if the blood sample is not contained and transported in ice water immediately. We presented two cases of falsely low measurement of blood uric acid caused by rasburicase and elaborated the proper method for collecting and transporting blood samples from patients using rasburicase. Cureus 2023-01-31 /pmc/articles/PMC9981216/ /pubmed/36874663 http://dx.doi.org/10.7759/cureus.34435 Text en Copyright © 2023, Yu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Medical Education
Yu, Lian
Xie, Yinjing
Ma, Jiangtao
Li, Guoqiang
Yuan, Xiaopeng
Rasburicase-Induced Falsely Low Measurement of Uric Acid in Tumor Lysis Syndrome: A Report of Two Cases
title Rasburicase-Induced Falsely Low Measurement of Uric Acid in Tumor Lysis Syndrome: A Report of Two Cases
title_full Rasburicase-Induced Falsely Low Measurement of Uric Acid in Tumor Lysis Syndrome: A Report of Two Cases
title_fullStr Rasburicase-Induced Falsely Low Measurement of Uric Acid in Tumor Lysis Syndrome: A Report of Two Cases
title_full_unstemmed Rasburicase-Induced Falsely Low Measurement of Uric Acid in Tumor Lysis Syndrome: A Report of Two Cases
title_short Rasburicase-Induced Falsely Low Measurement of Uric Acid in Tumor Lysis Syndrome: A Report of Two Cases
title_sort rasburicase-induced falsely low measurement of uric acid in tumor lysis syndrome: a report of two cases
topic Medical Education
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981216/
https://www.ncbi.nlm.nih.gov/pubmed/36874663
http://dx.doi.org/10.7759/cureus.34435
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