Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum

A 47‐year‐old woman with acute intermittent porphyria (AIP) has had recurring symptoms after achieving biochemical normalization of her urinary 5‐aminolevulinic acid (ALA), porphobilinogen (PBG), and total porphyrins with givosiran. She has had normal liver tests, mildly decreased renal function, an...

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Detalles Bibliográficos
Autores principales: Ma, Christopher D., Faust, Denise, Bonkovsky, Herbert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981411/
https://www.ncbi.nlm.nih.gov/pubmed/36873084
http://dx.doi.org/10.1002/jmd2.12354
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author Ma, Christopher D.
Faust, Denise
Bonkovsky, Herbert L.
author_facet Ma, Christopher D.
Faust, Denise
Bonkovsky, Herbert L.
author_sort Ma, Christopher D.
collection PubMed
description A 47‐year‐old woman with acute intermittent porphyria (AIP) has had recurring symptoms after achieving biochemical normalization of her urinary 5‐aminolevulinic acid (ALA), porphobilinogen (PBG), and total porphyrins with givosiran. She has had normal liver tests, mildly decreased renal function, and sustained normal urinary ALA, PBG, and porphyrins with no rebound in her laboratory test results throughout treatment. She continues to tolerate monthly givosiran injections with no adverse effects, but she still experiences what she believes are acute porphyric attacks every 1–2 months.
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spelling pubmed-99814112023-03-04 Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum Ma, Christopher D. Faust, Denise Bonkovsky, Herbert L. JIMD Rep Case Reports A 47‐year‐old woman with acute intermittent porphyria (AIP) has had recurring symptoms after achieving biochemical normalization of her urinary 5‐aminolevulinic acid (ALA), porphobilinogen (PBG), and total porphyrins with givosiran. She has had normal liver tests, mildly decreased renal function, and sustained normal urinary ALA, PBG, and porphyrins with no rebound in her laboratory test results throughout treatment. She continues to tolerate monthly givosiran injections with no adverse effects, but she still experiences what she believes are acute porphyric attacks every 1–2 months. John Wiley & Sons, Inc. 2022-12-13 /pmc/articles/PMC9981411/ /pubmed/36873084 http://dx.doi.org/10.1002/jmd2.12354 Text en © 2022 The Authors. JIMD Reports published by John Wiley & Sons Ltd on behalf of SSIEM. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Ma, Christopher D.
Faust, Denise
Bonkovsky, Herbert L.
Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum
title Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum
title_full Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum
title_fullStr Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum
title_full_unstemmed Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum
title_short Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum
title_sort recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—an ongoing clinical conundrum
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981411/
https://www.ncbi.nlm.nih.gov/pubmed/36873084
http://dx.doi.org/10.1002/jmd2.12354
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