Cargando…

Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer

Breast invasive cancer (BRCA) is the most common malignancy and the second leading cause of malignancy death among women. Signal transducers and activators of transcription (STAT) family played a vital role in regulating certain biological processes and could serve as biomarkers for many diseases or...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jiaying, Li, Li, Mahesutihan, Gulijiang, Meng, Juanjuan, Chen, Yuan, Lv, Jingsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981440/
https://www.ncbi.nlm.nih.gov/pubmed/36862902
http://dx.doi.org/10.1097/MD.0000000000032972
_version_ 1784900103465598976
author Li, Jiaying
Li, Li
Mahesutihan, Gulijiang
Meng, Juanjuan
Chen, Yuan
Lv, Jingsen
author_facet Li, Jiaying
Li, Li
Mahesutihan, Gulijiang
Meng, Juanjuan
Chen, Yuan
Lv, Jingsen
author_sort Li, Jiaying
collection PubMed
description Breast invasive cancer (BRCA) is the most common malignancy and the second leading cause of malignancy death among women. Signal transducers and activators of transcription (STAT) family played a vital role in regulating certain biological processes and could serve as biomarkers for many diseases or cancers. METHODS: The expression, prognostic value, and clinical functions of STAT family in BRCA were evaluated with several bioinformatics web portals. RESULTS: The expression of STAT5A/5B were downregulated in BRCA in subgroup analyses based on race, age, gender, race, subclasses, tumor histology, menopause status, nodal metastasis status, and TP53 mutation. BRCA patients with high STAT5B expression had a better overall survival, relapse free survival, MDFS and post progression survival. STAT5B expression level can impact the prognosis in BRCA patients with positive PR status, negative Her2 status and wild type TP53. Moreover, STAT5B was positively correlated with immune cell infiltration and the level of immune biomarkers. Drug sensitivity revealed that low STAT5B expression was resistant to the many small molecules or drugs. Functional enrichment analysis revealed that STAT5B was involved in adaptive immune response, translational initiation, JAK-STAT signaling pathway, Ribosome, NF-kappa B signaling pathway and Cell adhesion molecules. CONCLUSIONS: STAT5B was a biomarker associated with prognosis and immune infiltration in breast cancer.
format Online
Article
Text
id pubmed-9981440
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-99814402023-03-04 Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer Li, Jiaying Li, Li Mahesutihan, Gulijiang Meng, Juanjuan Chen, Yuan Lv, Jingsen Medicine (Baltimore) 5700 Breast invasive cancer (BRCA) is the most common malignancy and the second leading cause of malignancy death among women. Signal transducers and activators of transcription (STAT) family played a vital role in regulating certain biological processes and could serve as biomarkers for many diseases or cancers. METHODS: The expression, prognostic value, and clinical functions of STAT family in BRCA were evaluated with several bioinformatics web portals. RESULTS: The expression of STAT5A/5B were downregulated in BRCA in subgroup analyses based on race, age, gender, race, subclasses, tumor histology, menopause status, nodal metastasis status, and TP53 mutation. BRCA patients with high STAT5B expression had a better overall survival, relapse free survival, MDFS and post progression survival. STAT5B expression level can impact the prognosis in BRCA patients with positive PR status, negative Her2 status and wild type TP53. Moreover, STAT5B was positively correlated with immune cell infiltration and the level of immune biomarkers. Drug sensitivity revealed that low STAT5B expression was resistant to the many small molecules or drugs. Functional enrichment analysis revealed that STAT5B was involved in adaptive immune response, translational initiation, JAK-STAT signaling pathway, Ribosome, NF-kappa B signaling pathway and Cell adhesion molecules. CONCLUSIONS: STAT5B was a biomarker associated with prognosis and immune infiltration in breast cancer. Lippincott Williams & Wilkins 2023-03-03 /pmc/articles/PMC9981440/ /pubmed/36862902 http://dx.doi.org/10.1097/MD.0000000000032972 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Li, Jiaying
Li, Li
Mahesutihan, Gulijiang
Meng, Juanjuan
Chen, Yuan
Lv, Jingsen
Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer
title Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer
title_full Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer
title_fullStr Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer
title_full_unstemmed Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer
title_short Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer
title_sort identification of stat5b as a biomarker associated with prognosis and immune infiltration in breast cancer
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981440/
https://www.ncbi.nlm.nih.gov/pubmed/36862902
http://dx.doi.org/10.1097/MD.0000000000032972
work_keys_str_mv AT lijiaying identificationofstat5basabiomarkerassociatedwithprognosisandimmuneinfiltrationinbreastcancer
AT lili identificationofstat5basabiomarkerassociatedwithprognosisandimmuneinfiltrationinbreastcancer
AT mahesutihangulijiang identificationofstat5basabiomarkerassociatedwithprognosisandimmuneinfiltrationinbreastcancer
AT mengjuanjuan identificationofstat5basabiomarkerassociatedwithprognosisandimmuneinfiltrationinbreastcancer
AT chenyuan identificationofstat5basabiomarkerassociatedwithprognosisandimmuneinfiltrationinbreastcancer
AT lvjingsen identificationofstat5basabiomarkerassociatedwithprognosisandimmuneinfiltrationinbreastcancer