P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis

Medulloblastoma is the most common malignant paediatric brain tumour, with ~30% mediated by Sonic hedgehog signalling. Vismodegib-mediated inhibition of the Sonic hedgehog effector Smoothened inhibits tumour growth but causes growth plate fusion at effective doses. Here, we report a nanotherapeutic...

Descripción completa

Detalles Bibliográficos
Autores principales: Tylawsky, Daniel E., Kiguchi, Hiroto, Vaynshteyn, Jake, Gerwin, Jeffrey, Shah, Janki, Islam, Taseen, Boyer, Jacob A., Boué, Daniel R., Snuderl, Matija, Greenblatt, Matthew B., Shamay, Yosi, Raju, G. Praveen, Heller, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981459/
https://www.ncbi.nlm.nih.gov/pubmed/36864161
http://dx.doi.org/10.1038/s41563-023-01481-9

Ejemplares similares

Ejemplares similares