Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer

We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8(+) cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expand...

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Autores principales: Gkika, Eleni, Firat, Elke, Adebahr, Sonja, Graf, Erika, Popp, Ilinca, Radicioni, Gianluca, Lo, Simon S., Nestle, Ursula, Nicolay, Nils H., Niedermann, Gabriele, Duda, Dan G., Grosu, Anca-L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981559/
https://www.ncbi.nlm.nih.gov/pubmed/36864234
http://dx.doi.org/10.1038/s41698-023-00358-z
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author Gkika, Eleni
Firat, Elke
Adebahr, Sonja
Graf, Erika
Popp, Ilinca
Radicioni, Gianluca
Lo, Simon S.
Nestle, Ursula
Nicolay, Nils H.
Niedermann, Gabriele
Duda, Dan G.
Grosu, Anca-L.
author_facet Gkika, Eleni
Firat, Elke
Adebahr, Sonja
Graf, Erika
Popp, Ilinca
Radicioni, Gianluca
Lo, Simon S.
Nestle, Ursula
Nicolay, Nils H.
Niedermann, Gabriele
Duda, Dan G.
Grosu, Anca-L.
author_sort Gkika, Eleni
collection PubMed
description We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8(+) cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67(+)CD8(+) and Ki-67(+)CD4(+) T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.
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spelling pubmed-99815592023-03-04 Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer Gkika, Eleni Firat, Elke Adebahr, Sonja Graf, Erika Popp, Ilinca Radicioni, Gianluca Lo, Simon S. Nestle, Ursula Nicolay, Nils H. Niedermann, Gabriele Duda, Dan G. Grosu, Anca-L. NPJ Precis Oncol Brief Communication We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8(+) cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67(+)CD8(+) and Ki-67(+)CD4(+) T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment. Nature Publishing Group UK 2023-03-02 /pmc/articles/PMC9981559/ /pubmed/36864234 http://dx.doi.org/10.1038/s41698-023-00358-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Gkika, Eleni
Firat, Elke
Adebahr, Sonja
Graf, Erika
Popp, Ilinca
Radicioni, Gianluca
Lo, Simon S.
Nestle, Ursula
Nicolay, Nils H.
Niedermann, Gabriele
Duda, Dan G.
Grosu, Anca-L.
Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
title Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
title_full Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
title_fullStr Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
title_full_unstemmed Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
title_short Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
title_sort systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981559/
https://www.ncbi.nlm.nih.gov/pubmed/36864234
http://dx.doi.org/10.1038/s41698-023-00358-z
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