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TRPV1 regulates ApoE4-disrupted intracellular lipid homeostasis and decreases synaptic phagocytosis by microglia

Although the ε4 allele of the apolipoprotein E (ApoE4) gene has been established as a genetic risk factor for many neurodegenerative diseases, including Alzheimer’s disease, the mechanism of action remains poorly understood. Transient receptor potential vanilloid 1 (TRPV1) was reported to regulate a...

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Detalles Bibliográficos
Autores principales: Wang, Chenfei, Lu, Jia, Sha, Xudong, Qiu, Yu, Chen, Hongzhuan, Yu, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981624/
https://www.ncbi.nlm.nih.gov/pubmed/36720919
http://dx.doi.org/10.1038/s12276-023-00935-z