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Targeting matrix metalloproteases in diabetic wound healing

Chronic inflammation participates in the progression of multiple chronic diseases, including obesity, diabetes mellitus (DM), and DM related complications. Diabetic ulcer, characterized by chronic wounds that are recalcitrant to healing, is a serious complication of DM tremendously affecting the qua...

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Autores principales: Chen, Junren, Qin, Siqi, Liu, Shengmeng, Zhong, Kexin, Jing, Yiqi, Wu, Xuan, Peng, Fu, Li, Dan, Peng, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981633/
https://www.ncbi.nlm.nih.gov/pubmed/36875064
http://dx.doi.org/10.3389/fimmu.2023.1089001
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author Chen, Junren
Qin, Siqi
Liu, Shengmeng
Zhong, Kexin
Jing, Yiqi
Wu, Xuan
Peng, Fu
Li, Dan
Peng, Cheng
author_facet Chen, Junren
Qin, Siqi
Liu, Shengmeng
Zhong, Kexin
Jing, Yiqi
Wu, Xuan
Peng, Fu
Li, Dan
Peng, Cheng
author_sort Chen, Junren
collection PubMed
description Chronic inflammation participates in the progression of multiple chronic diseases, including obesity, diabetes mellitus (DM), and DM related complications. Diabetic ulcer, characterized by chronic wounds that are recalcitrant to healing, is a serious complication of DM tremendously affecting the quality of life of patients and imposing a costly medical burden on society. Matrix metalloproteases (MMPs) are a family of zinc endopeptidases with the capacity of degrading all the components of the extracellular matrix, which play a pivotal part in healing process under various conditions including DM. During diabetic wound healing, the dynamic changes of MMPs in the serum, skin tissues, and wound fluid of patients are in connection with the degree of wound recovery, suggesting that MMPs can function as essential biomarkers for the diagnosis of diabetic ulcer. MMPs participate in various biological processes relevant to diabetic ulcer, such as ECM secretion, granulation tissue configuration, angiogenesis, collagen growth, re-epithelization, inflammatory response, as well as oxidative stress, thus, seeking and developing agents targeting MMPs has emerged as a potential way to treat diabetic ulcer. Natural products especially flavonoids, polysaccharides, alkaloids, polypeptides, and estrogens extracted from herbs, vegetables, as well as animals that have been extensively illustrated to treat diabetic ulcer through targeting MMPs-mediated signaling pathways, are discussed in this review and may contribute to the development of functional foods or drug candidates for diabetic ulcer therapy. This review highlights the regulation of MMPs in diabetic wound healing, and the potential therapeutic ability of natural products for diabetic wound healing by targeting MMPs.
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spelling pubmed-99816332023-03-04 Targeting matrix metalloproteases in diabetic wound healing Chen, Junren Qin, Siqi Liu, Shengmeng Zhong, Kexin Jing, Yiqi Wu, Xuan Peng, Fu Li, Dan Peng, Cheng Front Immunol Immunology Chronic inflammation participates in the progression of multiple chronic diseases, including obesity, diabetes mellitus (DM), and DM related complications. Diabetic ulcer, characterized by chronic wounds that are recalcitrant to healing, is a serious complication of DM tremendously affecting the quality of life of patients and imposing a costly medical burden on society. Matrix metalloproteases (MMPs) are a family of zinc endopeptidases with the capacity of degrading all the components of the extracellular matrix, which play a pivotal part in healing process under various conditions including DM. During diabetic wound healing, the dynamic changes of MMPs in the serum, skin tissues, and wound fluid of patients are in connection with the degree of wound recovery, suggesting that MMPs can function as essential biomarkers for the diagnosis of diabetic ulcer. MMPs participate in various biological processes relevant to diabetic ulcer, such as ECM secretion, granulation tissue configuration, angiogenesis, collagen growth, re-epithelization, inflammatory response, as well as oxidative stress, thus, seeking and developing agents targeting MMPs has emerged as a potential way to treat diabetic ulcer. Natural products especially flavonoids, polysaccharides, alkaloids, polypeptides, and estrogens extracted from herbs, vegetables, as well as animals that have been extensively illustrated to treat diabetic ulcer through targeting MMPs-mediated signaling pathways, are discussed in this review and may contribute to the development of functional foods or drug candidates for diabetic ulcer therapy. This review highlights the regulation of MMPs in diabetic wound healing, and the potential therapeutic ability of natural products for diabetic wound healing by targeting MMPs. Frontiers Media S.A. 2023-02-17 /pmc/articles/PMC9981633/ /pubmed/36875064 http://dx.doi.org/10.3389/fimmu.2023.1089001 Text en Copyright © 2023 Chen, Qin, Liu, Zhong, Jing, Wu, Peng, Li and Peng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Junren
Qin, Siqi
Liu, Shengmeng
Zhong, Kexin
Jing, Yiqi
Wu, Xuan
Peng, Fu
Li, Dan
Peng, Cheng
Targeting matrix metalloproteases in diabetic wound healing
title Targeting matrix metalloproteases in diabetic wound healing
title_full Targeting matrix metalloproteases in diabetic wound healing
title_fullStr Targeting matrix metalloproteases in diabetic wound healing
title_full_unstemmed Targeting matrix metalloproteases in diabetic wound healing
title_short Targeting matrix metalloproteases in diabetic wound healing
title_sort targeting matrix metalloproteases in diabetic wound healing
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981633/
https://www.ncbi.nlm.nih.gov/pubmed/36875064
http://dx.doi.org/10.3389/fimmu.2023.1089001
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