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Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE

INTRODUCTION: Alzheimer’s disease (AD) is associated with amyloid β-protein 1-42 (Aβ42) accumulation in the brain. Aβ42 and Aβ40 are the major two species generated from amyloid precursor protein. We found that angiotensin-converting enzyme (ACE) converts neurotoxic Aβ42 to neuroprotective Aβ40 in a...

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Detalles Bibliográficos
Autores principales:	Gao, Yuan, Sun, Yang, Islam, Sadequl, Nakamura, Tomohisa, Tomita, Taisuke, Zou, Kun, Michikawa, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981673/ https://www.ncbi.nlm.nih.gov/pubmed/36875692 http://dx.doi.org/10.3389/fnagi.2023.1098034

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