Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-con...

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Detalles Bibliográficos
Autores principales: Upadhyayula, Pavan S., Higgins, Dominique M., Mela, Angeliki, Banu, Matei, Dovas, Athanassios, Zandkarimi, Fereshteh, Patel, Purvi, Mahajan, Aayushi, Humala, Nelson, Nguyen, Trang T. T., Chaudhary, Kunal R., Liao, Lillian, Argenziano, Michael, Sudhakar, Tejaswi, Sperring, Colin P., Shapiro, Benjamin L., Ahmed, Eman R., Kinslow, Connor, Ye, Ling F., Siegelin, Markus D., Cheng, Simon, Soni, Rajesh, Bruce, Jeffrey N., Stockwell, Brent R., Canoll, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981683/
https://www.ncbi.nlm.nih.gov/pubmed/36864031
http://dx.doi.org/10.1038/s41467-023-36630-w

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