PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment

Telomeres are nucleoprotein structures at eukaryotic chromosome termini. Their stability is preserved by a six-protein complex named shelterin. Among these, TRF1 binds telomere duplex and assists DNA replication with mechanisms only partly clarified. Here we found that poly (ADP-ribose) polymerase 1...

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Detalles Bibliográficos
Autores principales: Maresca, C., Dello Stritto, A., D’Angelo, C., Petti, E., Rizzo, A., Vertecchi, E., Berardinelli, F., Bonanni, L., Sgura, A., Antoccia, A., Graziani, G., Biroccio, A., Salvati, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981704/
https://www.ncbi.nlm.nih.gov/pubmed/36864251
http://dx.doi.org/10.1038/s42003-023-04596-6

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