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Clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (aSAH) complications

Post-aSAH sequela is characterized by the onset of life-threatening complications along with the upregulated underlying inflammation. Cerebral vasospasm (CVS) is one of the most frequent complication after aSAH, which contributes majorly to delayed cerebral ischemia and poor clinical outcome. The ob...

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Autores principales: Fischer, Igor, Chaudhry, Shafqat Rasul, Hänggi, Daniel, Muhammad, Sajjad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981718/
https://www.ncbi.nlm.nih.gov/pubmed/36864213
http://dx.doi.org/10.1007/s10143-023-01967-9
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author Fischer, Igor
Chaudhry, Shafqat Rasul
Hänggi, Daniel
Muhammad, Sajjad
author_facet Fischer, Igor
Chaudhry, Shafqat Rasul
Hänggi, Daniel
Muhammad, Sajjad
author_sort Fischer, Igor
collection PubMed
description Post-aSAH sequela is characterized by the onset of life-threatening complications along with the upregulated underlying inflammation. Cerebral vasospasm (CVS) is one of the most frequent complication after aSAH, which contributes majorly to delayed cerebral ischemia and poor clinical outcome. The objective of this study was to identify the clusters of serum biomarkers that are associated with cerebral vasospasm (CVS) after suffering from aneurysmal subarachnoid hemorrhage (aSAH). In this single-center study, serum concentrations of 10 potential biomarkers, together with clinical and demographic parameters, for 66 aSAH patients were recorded within 24 h after aSAH. The dataset was split into a training set (43 patients) and a validation set. Correlation heatmaps for both datasets were computed. Variables with inconsistent correlations on the two subsets were excluded. Clusters of relevant biomarkers were identified on the complete set, separately for patients who developed post-aSAH CVS and those who did not. Two clusters were found to be specific for patients who suffered from CVS: mitochondrial gene fragments (cytochrome B (Cyt-B), cytochrome C oxidase subunit-1 (Cox-1), displacement loop (D-loop), and IL-23, and the other one, containing IL-6, IL-10, age, and Hunt and Hess score. Clusters of serum biomarkers, analyzed within 24 h of the onset of aSAH, days before the CVS development, are expressed differently in patients suffering from post-aSAH CVS, compared to patients without CVS. This suggests that these biomarkers may be involved in the pathophysiological processes leading to CVS and may be used as its early predictors. These interesting findings are potentially highly relevant for the management of CVS and call for validation on a larger sample of patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10143-023-01967-9.
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spelling pubmed-99817182023-03-04 Clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (aSAH) complications Fischer, Igor Chaudhry, Shafqat Rasul Hänggi, Daniel Muhammad, Sajjad Neurosurg Rev Research Post-aSAH sequela is characterized by the onset of life-threatening complications along with the upregulated underlying inflammation. Cerebral vasospasm (CVS) is one of the most frequent complication after aSAH, which contributes majorly to delayed cerebral ischemia and poor clinical outcome. The objective of this study was to identify the clusters of serum biomarkers that are associated with cerebral vasospasm (CVS) after suffering from aneurysmal subarachnoid hemorrhage (aSAH). In this single-center study, serum concentrations of 10 potential biomarkers, together with clinical and demographic parameters, for 66 aSAH patients were recorded within 24 h after aSAH. The dataset was split into a training set (43 patients) and a validation set. Correlation heatmaps for both datasets were computed. Variables with inconsistent correlations on the two subsets were excluded. Clusters of relevant biomarkers were identified on the complete set, separately for patients who developed post-aSAH CVS and those who did not. Two clusters were found to be specific for patients who suffered from CVS: mitochondrial gene fragments (cytochrome B (Cyt-B), cytochrome C oxidase subunit-1 (Cox-1), displacement loop (D-loop), and IL-23, and the other one, containing IL-6, IL-10, age, and Hunt and Hess score. Clusters of serum biomarkers, analyzed within 24 h of the onset of aSAH, days before the CVS development, are expressed differently in patients suffering from post-aSAH CVS, compared to patients without CVS. This suggests that these biomarkers may be involved in the pathophysiological processes leading to CVS and may be used as its early predictors. These interesting findings are potentially highly relevant for the management of CVS and call for validation on a larger sample of patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10143-023-01967-9. Springer Berlin Heidelberg 2023-03-03 2023 /pmc/articles/PMC9981718/ /pubmed/36864213 http://dx.doi.org/10.1007/s10143-023-01967-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Fischer, Igor
Chaudhry, Shafqat Rasul
Hänggi, Daniel
Muhammad, Sajjad
Clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (aSAH) complications
title Clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (aSAH) complications
title_full Clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (aSAH) complications
title_fullStr Clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (aSAH) complications
title_full_unstemmed Clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (aSAH) complications
title_short Clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (aSAH) complications
title_sort clustering of serum biomarkers involved in post-aneurysmal subarachnoid hemorrhage (asah) complications
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981718/
https://www.ncbi.nlm.nih.gov/pubmed/36864213
http://dx.doi.org/10.1007/s10143-023-01967-9
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