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Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes
Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders. We recently reported that RFX7 responds to p53 signaling and cellular stress. Furthermore, we...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981735/ https://www.ncbi.nlm.nih.gov/pubmed/36864036 http://dx.doi.org/10.1038/s41420-023-01378-1 |
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author | Schwab, Katjana Coronel, Luis Riege, Konstantin Sacramento, Erika K. Rahnis, Norman Häckes, David Cirri, Emilio Groth, Marco Hoffmann, Steve Fischer, Martin |
author_facet | Schwab, Katjana Coronel, Luis Riege, Konstantin Sacramento, Erika K. Rahnis, Norman Häckes, David Cirri, Emilio Groth, Marco Hoffmann, Steve Fischer, Martin |
author_sort | Schwab, Katjana |
collection | PubMed |
description | Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders. We recently reported that RFX7 responds to p53 signaling and cellular stress. Furthermore, we found RFX7 target genes to be dysregulated in numerous cancer types also beyond the hematological system. However, our understanding of RFX7’s target gene network and its role in health and disease remains limited. Here, we generated RFX7 knock-out cells and employed a multi-omics approach integrating transcriptome, cistrome, and proteome data to obtain a more comprehensive picture of RFX7 targets. We identify novel target genes linked to RFX7’s tumor suppressor function and underscoring its potential role in neurological disorders. Importantly, our data reveal RFX7 as a mechanistic link that enables the activation of these genes in response to p53 signaling. |
format | Online Article Text |
id | pubmed-9981735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99817352023-03-04 Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes Schwab, Katjana Coronel, Luis Riege, Konstantin Sacramento, Erika K. Rahnis, Norman Häckes, David Cirri, Emilio Groth, Marco Hoffmann, Steve Fischer, Martin Cell Death Discov Article Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders. We recently reported that RFX7 responds to p53 signaling and cellular stress. Furthermore, we found RFX7 target genes to be dysregulated in numerous cancer types also beyond the hematological system. However, our understanding of RFX7’s target gene network and its role in health and disease remains limited. Here, we generated RFX7 knock-out cells and employed a multi-omics approach integrating transcriptome, cistrome, and proteome data to obtain a more comprehensive picture of RFX7 targets. We identify novel target genes linked to RFX7’s tumor suppressor function and underscoring its potential role in neurological disorders. Importantly, our data reveal RFX7 as a mechanistic link that enables the activation of these genes in response to p53 signaling. Nature Publishing Group UK 2023-03-03 /pmc/articles/PMC9981735/ /pubmed/36864036 http://dx.doi.org/10.1038/s41420-023-01378-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Schwab, Katjana Coronel, Luis Riege, Konstantin Sacramento, Erika K. Rahnis, Norman Häckes, David Cirri, Emilio Groth, Marco Hoffmann, Steve Fischer, Martin Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes |
title | Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes |
title_full | Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes |
title_fullStr | Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes |
title_full_unstemmed | Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes |
title_short | Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes |
title_sort | multi-omics analysis identifies rfx7 targets involved in tumor suppression and neuronal processes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981735/ https://www.ncbi.nlm.nih.gov/pubmed/36864036 http://dx.doi.org/10.1038/s41420-023-01378-1 |
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