Cargando…

Risk evaluation and mitigation strategies for newly detected SARS‐CoV‐2 Omicron BF.7 subvariant: A brief report

Mutations of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are always going on. The pathogenic characteristics of a virus are influenced by mutations in the viral genome. Therefore, the recently identified Omicron BF.7 subvariant might harm humans. Here we aimed to evaluate the po...

Descripción completa

Detalles Bibliográficos
Autores principales: Nazmunnahar, Ahmed, Iftekhar, Islam, Md. Rabiul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981880/
https://www.ncbi.nlm.nih.gov/pubmed/36875932
http://dx.doi.org/10.1002/hsr2.1127
_version_ 1784900201687810048
author Nazmunnahar,
Ahmed, Iftekhar
Islam, Md. Rabiul
author_facet Nazmunnahar,
Ahmed, Iftekhar
Islam, Md. Rabiul
author_sort Nazmunnahar,
collection PubMed
description Mutations of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are always going on. The pathogenic characteristics of a virus are influenced by mutations in the viral genome. Therefore, the recently identified Omicron BF.7 subvariant might harm humans. Here we aimed to evaluate the potential risks of this newly detected variant and identify possible mitigation strategies. The frequent mutation associated with SARS‐CoV‐2 makes it more concerning compared to other viruses. The Omicron variant of SARS‐CoV‐2 has unique changes in the structural amino acid. Thus, Omicron subvariants are different from other coronavirus variants in terms of viral spread, disease severity, vaccine neutralization capacity, and immunity evade. Moreover, Omicron subvariant BF.7 is an offspring of BA.4 and BA.5. Similar S glycoprotein sequences are present among BF.7, BA.4, and BA.5. There is a change in the R346T gene in the receptor binding site of Omicron BF.7 than other Omicron subvariants. This BF.7 subvariant has created a limitation in current monoclonal antibody therapy. Omicron has mutated since it emerged, and the subvariants are improving in terms of transmission as well as antibody evasion. Therefore, the healthcare authorities should pay attention to the BF.7 subvariant of Omicron. The recent upsurge may create havoc all of a sudden. Scientists and researchers across the world should monitor the nature and mutations of SARS‐CoV‐2 variants. Also, they should find ways to fight the current circulatory variants and any future mutations.
format Online
Article
Text
id pubmed-9981880
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-99818802023-03-04 Risk evaluation and mitigation strategies for newly detected SARS‐CoV‐2 Omicron BF.7 subvariant: A brief report Nazmunnahar, Ahmed, Iftekhar Islam, Md. Rabiul Health Sci Rep Perspective Mutations of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are always going on. The pathogenic characteristics of a virus are influenced by mutations in the viral genome. Therefore, the recently identified Omicron BF.7 subvariant might harm humans. Here we aimed to evaluate the potential risks of this newly detected variant and identify possible mitigation strategies. The frequent mutation associated with SARS‐CoV‐2 makes it more concerning compared to other viruses. The Omicron variant of SARS‐CoV‐2 has unique changes in the structural amino acid. Thus, Omicron subvariants are different from other coronavirus variants in terms of viral spread, disease severity, vaccine neutralization capacity, and immunity evade. Moreover, Omicron subvariant BF.7 is an offspring of BA.4 and BA.5. Similar S glycoprotein sequences are present among BF.7, BA.4, and BA.5. There is a change in the R346T gene in the receptor binding site of Omicron BF.7 than other Omicron subvariants. This BF.7 subvariant has created a limitation in current monoclonal antibody therapy. Omicron has mutated since it emerged, and the subvariants are improving in terms of transmission as well as antibody evasion. Therefore, the healthcare authorities should pay attention to the BF.7 subvariant of Omicron. The recent upsurge may create havoc all of a sudden. Scientists and researchers across the world should monitor the nature and mutations of SARS‐CoV‐2 variants. Also, they should find ways to fight the current circulatory variants and any future mutations. John Wiley and Sons Inc. 2023-03-02 /pmc/articles/PMC9981880/ /pubmed/36875932 http://dx.doi.org/10.1002/hsr2.1127 Text en © 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Perspective
Nazmunnahar,
Ahmed, Iftekhar
Islam, Md. Rabiul
Risk evaluation and mitigation strategies for newly detected SARS‐CoV‐2 Omicron BF.7 subvariant: A brief report
title Risk evaluation and mitigation strategies for newly detected SARS‐CoV‐2 Omicron BF.7 subvariant: A brief report
title_full Risk evaluation and mitigation strategies for newly detected SARS‐CoV‐2 Omicron BF.7 subvariant: A brief report
title_fullStr Risk evaluation and mitigation strategies for newly detected SARS‐CoV‐2 Omicron BF.7 subvariant: A brief report
title_full_unstemmed Risk evaluation and mitigation strategies for newly detected SARS‐CoV‐2 Omicron BF.7 subvariant: A brief report
title_short Risk evaluation and mitigation strategies for newly detected SARS‐CoV‐2 Omicron BF.7 subvariant: A brief report
title_sort risk evaluation and mitigation strategies for newly detected sars‐cov‐2 omicron bf.7 subvariant: a brief report
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981880/
https://www.ncbi.nlm.nih.gov/pubmed/36875932
http://dx.doi.org/10.1002/hsr2.1127
work_keys_str_mv AT nazmunnahar riskevaluationandmitigationstrategiesfornewlydetectedsarscov2omicronbf7subvariantabriefreport
AT ahmediftekhar riskevaluationandmitigationstrategiesfornewlydetectedsarscov2omicronbf7subvariantabriefreport
AT islammdrabiul riskevaluationandmitigationstrategiesfornewlydetectedsarscov2omicronbf7subvariantabriefreport