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The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy

Coronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower and upper respiratory tract in humans. SARS-CoV-2 infection is associated with the induction of a cascade of uncontrolled i...

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Autores principales: Hasankhani, Aliakbar, Bahrami, Abolfazl, Tavakoli-Far, Bahareh, Iranshahi, Setare, Ghaemi, Farnaz, Akbarizadeh, Majid Reza, Amin, Ali H., Abedi Kiasari, Bahman, Mohammadzadeh Shabestari, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981974/
https://www.ncbi.nlm.nih.gov/pubmed/36875108
http://dx.doi.org/10.3389/fimmu.2023.1127358
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author Hasankhani, Aliakbar
Bahrami, Abolfazl
Tavakoli-Far, Bahareh
Iranshahi, Setare
Ghaemi, Farnaz
Akbarizadeh, Majid Reza
Amin, Ali H.
Abedi Kiasari, Bahman
Mohammadzadeh Shabestari, Alireza
author_facet Hasankhani, Aliakbar
Bahrami, Abolfazl
Tavakoli-Far, Bahareh
Iranshahi, Setare
Ghaemi, Farnaz
Akbarizadeh, Majid Reza
Amin, Ali H.
Abedi Kiasari, Bahman
Mohammadzadeh Shabestari, Alireza
author_sort Hasankhani, Aliakbar
collection PubMed
description Coronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower and upper respiratory tract in humans. SARS-CoV-2 infection is associated with the induction of a cascade of uncontrolled inflammatory responses in the host, ultimately leading to hyperinflammation or cytokine storm. Indeed, cytokine storm is a hallmark of SARS-CoV-2 immunopathogenesis, directly related to the severity of the disease and mortality in COVID-19 patients. Considering the lack of any definitive treatment for COVID-19, targeting key inflammatory factors to regulate the inflammatory response in COVID-19 patients could be a fundamental step to developing effective therapeutic strategies against SARS-CoV-2 infection. Currently, in addition to well-defined metabolic actions, especially lipid metabolism and glucose utilization, there is growing evidence of a central role of the ligand-dependent nuclear receptors and peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARβ/δ, and PPARγ in the control of inflammatory signals in various human inflammatory diseases. This makes them attractive targets for developing therapeutic approaches to control/suppress the hyperinflammatory response in patients with severe COVID-19. In this review, we (1) investigate the anti-inflammatory mechanisms mediated by PPARs and their ligands during SARS-CoV-2 infection, and (2) on the basis of the recent literature, highlight the importance of PPAR subtypes for the development of promising therapeutic approaches against the cytokine storm in severe COVID-19 patients.
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spelling pubmed-99819742023-03-04 The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy Hasankhani, Aliakbar Bahrami, Abolfazl Tavakoli-Far, Bahareh Iranshahi, Setare Ghaemi, Farnaz Akbarizadeh, Majid Reza Amin, Ali H. Abedi Kiasari, Bahman Mohammadzadeh Shabestari, Alireza Front Immunol Immunology Coronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower and upper respiratory tract in humans. SARS-CoV-2 infection is associated with the induction of a cascade of uncontrolled inflammatory responses in the host, ultimately leading to hyperinflammation or cytokine storm. Indeed, cytokine storm is a hallmark of SARS-CoV-2 immunopathogenesis, directly related to the severity of the disease and mortality in COVID-19 patients. Considering the lack of any definitive treatment for COVID-19, targeting key inflammatory factors to regulate the inflammatory response in COVID-19 patients could be a fundamental step to developing effective therapeutic strategies against SARS-CoV-2 infection. Currently, in addition to well-defined metabolic actions, especially lipid metabolism and glucose utilization, there is growing evidence of a central role of the ligand-dependent nuclear receptors and peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARβ/δ, and PPARγ in the control of inflammatory signals in various human inflammatory diseases. This makes them attractive targets for developing therapeutic approaches to control/suppress the hyperinflammatory response in patients with severe COVID-19. In this review, we (1) investigate the anti-inflammatory mechanisms mediated by PPARs and their ligands during SARS-CoV-2 infection, and (2) on the basis of the recent literature, highlight the importance of PPAR subtypes for the development of promising therapeutic approaches against the cytokine storm in severe COVID-19 patients. Frontiers Media S.A. 2023-02-17 /pmc/articles/PMC9981974/ /pubmed/36875108 http://dx.doi.org/10.3389/fimmu.2023.1127358 Text en Copyright © 2023 Hasankhani, Bahrami, Tavakoli-Far, Iranshahi, Ghaemi, Akbarizadeh, Amin, Abedi Kiasari and Mohammadzadeh Shabestari https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hasankhani, Aliakbar
Bahrami, Abolfazl
Tavakoli-Far, Bahareh
Iranshahi, Setare
Ghaemi, Farnaz
Akbarizadeh, Majid Reza
Amin, Ali H.
Abedi Kiasari, Bahman
Mohammadzadeh Shabestari, Alireza
The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy
title The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy
title_full The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy
title_fullStr The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy
title_full_unstemmed The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy
title_short The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy
title_sort role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by sars-cov-2 infection: a perspective for covid-19 therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981974/
https://www.ncbi.nlm.nih.gov/pubmed/36875108
http://dx.doi.org/10.3389/fimmu.2023.1127358
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