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Performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50
The increased demand for colonoscopy combined with increased incidence of colorectal cancer (CRC) among younger populations presents a need to determine FIT performance among individuals in this age group. We conducted a systematic review to assess test performance characteristics of FIT in detectin...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981994/ https://www.ncbi.nlm.nih.gov/pubmed/36875511 http://dx.doi.org/10.1016/j.pmedr.2023.102124 |
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author | Heer, Emily Ruan, Yibing Pader, Joy Mah, Brittany Ricci, Christina Nguyen, Teresa Chow, Kristian Ford-Sahibzada, Chelsea Gogna, Priyanka Poirier, Abbey Forbes, Nauzer Heitman, Steve J. Hilsden, Robert J. Brenner, Darren R. |
author_facet | Heer, Emily Ruan, Yibing Pader, Joy Mah, Brittany Ricci, Christina Nguyen, Teresa Chow, Kristian Ford-Sahibzada, Chelsea Gogna, Priyanka Poirier, Abbey Forbes, Nauzer Heitman, Steve J. Hilsden, Robert J. Brenner, Darren R. |
author_sort | Heer, Emily |
collection | PubMed |
description | The increased demand for colonoscopy combined with increased incidence of colorectal cancer (CRC) among younger populations presents a need to determine FIT performance among individuals in this age group. We conducted a systematic review to assess test performance characteristics of FIT in detecting CRC and advanced neoplasia in younger age populations. A search through December 2022 identified published articles assessing the sensitivity and specificity of FIT for advanced neoplasia or CRC among populations under age 50. Following the search, 3 studies were included in the systematic review. Sensitivity to detect advanced neoplasia ranged from 0.19 to 0.36 and specificity between 0.94 and 0.97 and the overall sensitivity and specificity were 0.23 (0.17–0.30) and 0.96 (0.94–0.98), respectively. Two studies that assessed these metrics in multiple age categories found similar sensitivity and specificity across all age groups 30–49. Sensitivity and specificity to detect CRC was assessed in one study and found no significant differences by age groups. These results suggest that FIT performance may be lower for younger individuals compared to those typically screened for CRC. However, there were few studies available for analysis. Given increasing recommendations to expand screening in younger age groups, more research is needed to determine whether FIT is an adequate screening tool in this population. |
format | Online Article Text |
id | pubmed-9981994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-99819942023-03-04 Performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50 Heer, Emily Ruan, Yibing Pader, Joy Mah, Brittany Ricci, Christina Nguyen, Teresa Chow, Kristian Ford-Sahibzada, Chelsea Gogna, Priyanka Poirier, Abbey Forbes, Nauzer Heitman, Steve J. Hilsden, Robert J. Brenner, Darren R. Prev Med Rep Review Article The increased demand for colonoscopy combined with increased incidence of colorectal cancer (CRC) among younger populations presents a need to determine FIT performance among individuals in this age group. We conducted a systematic review to assess test performance characteristics of FIT in detecting CRC and advanced neoplasia in younger age populations. A search through December 2022 identified published articles assessing the sensitivity and specificity of FIT for advanced neoplasia or CRC among populations under age 50. Following the search, 3 studies were included in the systematic review. Sensitivity to detect advanced neoplasia ranged from 0.19 to 0.36 and specificity between 0.94 and 0.97 and the overall sensitivity and specificity were 0.23 (0.17–0.30) and 0.96 (0.94–0.98), respectively. Two studies that assessed these metrics in multiple age categories found similar sensitivity and specificity across all age groups 30–49. Sensitivity and specificity to detect CRC was assessed in one study and found no significant differences by age groups. These results suggest that FIT performance may be lower for younger individuals compared to those typically screened for CRC. However, there were few studies available for analysis. Given increasing recommendations to expand screening in younger age groups, more research is needed to determine whether FIT is an adequate screening tool in this population. 2023-02-07 /pmc/articles/PMC9981994/ /pubmed/36875511 http://dx.doi.org/10.1016/j.pmedr.2023.102124 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Heer, Emily Ruan, Yibing Pader, Joy Mah, Brittany Ricci, Christina Nguyen, Teresa Chow, Kristian Ford-Sahibzada, Chelsea Gogna, Priyanka Poirier, Abbey Forbes, Nauzer Heitman, Steve J. Hilsden, Robert J. Brenner, Darren R. Performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50 |
title | Performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50 |
title_full | Performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50 |
title_fullStr | Performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50 |
title_full_unstemmed | Performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50 |
title_short | Performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50 |
title_sort | performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50 |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981994/ https://www.ncbi.nlm.nih.gov/pubmed/36875511 http://dx.doi.org/10.1016/j.pmedr.2023.102124 |
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