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Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak
BACKGROUND: The presentation of mpox clade IIb during the 2022 outbreak overlaps with a range of other diseases. Understanding the factors associated with mpox is important for clinical decision making. METHODS: We described the characteristics of mpox patients who sought care at Belgian sexual heal...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982023/ https://www.ncbi.nlm.nih.gov/pubmed/36874154 http://dx.doi.org/10.1016/j.nmni.2023.101093 |
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author | Hens, Matilde Brosius, Isabel Berens-Riha, Nicole Coppens, Jasmine Van Gestel, Liesbeth Rutgers, Jojanneke Kenyon, Chris Soentjens, Patrick van Henten, Saskia Bracke, Stefanie Vanbaelen, Thibaut Vandenhoven, Leen Bottieau, Emmanuel Vercauteren, Koen Van Esbroeck, Marjan Liesenborghs, Laurens Van Dijck, Christophe |
author_facet | Hens, Matilde Brosius, Isabel Berens-Riha, Nicole Coppens, Jasmine Van Gestel, Liesbeth Rutgers, Jojanneke Kenyon, Chris Soentjens, Patrick van Henten, Saskia Bracke, Stefanie Vanbaelen, Thibaut Vandenhoven, Leen Bottieau, Emmanuel Vercauteren, Koen Van Esbroeck, Marjan Liesenborghs, Laurens Van Dijck, Christophe |
author_sort | Hens, Matilde |
collection | PubMed |
description | BACKGROUND: The presentation of mpox clade IIb during the 2022 outbreak overlaps with a range of other diseases. Understanding the factors associated with mpox is important for clinical decision making. METHODS: We described the characteristics of mpox patients who sought care at Belgian sexual health clinic. Furthermore we compared their characteristics to those of patients with a clinical suspicion of mpox but who tested negative on polymerase chain reaction. RESULTS: Between May 23 and September 20, 2022, 155 patients were diagnosed with mpox, and 51 patients with suspected symptoms tested negative. All mpox patients self-identified as men and 148/155 (95.5%) as gay or bisexual MSM. Systemic symptoms were present in 116/155 (74.8%) patients. All but 10 patients (145/155, 93.5%) presented with skin lesions. Other manifestations were lymphadenopathy (72/155, 46.5%), proctitis (50/155, 32.3%), urethritis (12/155, 7.7%), tonsillitis (2/155, 1.3%). Complications involved bacterial skin infection (13/155, 8.4%) and penile oedema with or without paraphimosis (4/155, 2.6%). In multivariable logistic regression models, the presence of lymphadenopathy (OR 3.79 95% CI 1.44–11.49), skin lesions (OR 4.35 95% CI 1.15–17.57) and proctitis (OR 9.41 95% CI 2.72–47.07) were associated with the diagnosis of mpox. There were no associations with age, HIV status, childhood smallpox vaccination, number of sexual partners and international travel. CONCLUSIONS: The presence of proctitis, lymphadenopathies and skin lesions should increase clinical suspicion of mpox in patients with compatible symptoms. |
format | Online Article Text |
id | pubmed-9982023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99820232023-03-04 Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak Hens, Matilde Brosius, Isabel Berens-Riha, Nicole Coppens, Jasmine Van Gestel, Liesbeth Rutgers, Jojanneke Kenyon, Chris Soentjens, Patrick van Henten, Saskia Bracke, Stefanie Vanbaelen, Thibaut Vandenhoven, Leen Bottieau, Emmanuel Vercauteren, Koen Van Esbroeck, Marjan Liesenborghs, Laurens Van Dijck, Christophe New Microbes New Infect Original Article BACKGROUND: The presentation of mpox clade IIb during the 2022 outbreak overlaps with a range of other diseases. Understanding the factors associated with mpox is important for clinical decision making. METHODS: We described the characteristics of mpox patients who sought care at Belgian sexual health clinic. Furthermore we compared their characteristics to those of patients with a clinical suspicion of mpox but who tested negative on polymerase chain reaction. RESULTS: Between May 23 and September 20, 2022, 155 patients were diagnosed with mpox, and 51 patients with suspected symptoms tested negative. All mpox patients self-identified as men and 148/155 (95.5%) as gay or bisexual MSM. Systemic symptoms were present in 116/155 (74.8%) patients. All but 10 patients (145/155, 93.5%) presented with skin lesions. Other manifestations were lymphadenopathy (72/155, 46.5%), proctitis (50/155, 32.3%), urethritis (12/155, 7.7%), tonsillitis (2/155, 1.3%). Complications involved bacterial skin infection (13/155, 8.4%) and penile oedema with or without paraphimosis (4/155, 2.6%). In multivariable logistic regression models, the presence of lymphadenopathy (OR 3.79 95% CI 1.44–11.49), skin lesions (OR 4.35 95% CI 1.15–17.57) and proctitis (OR 9.41 95% CI 2.72–47.07) were associated with the diagnosis of mpox. There were no associations with age, HIV status, childhood smallpox vaccination, number of sexual partners and international travel. CONCLUSIONS: The presence of proctitis, lymphadenopathies and skin lesions should increase clinical suspicion of mpox in patients with compatible symptoms. Elsevier 2023-02-09 /pmc/articles/PMC9982023/ /pubmed/36874154 http://dx.doi.org/10.1016/j.nmni.2023.101093 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Hens, Matilde Brosius, Isabel Berens-Riha, Nicole Coppens, Jasmine Van Gestel, Liesbeth Rutgers, Jojanneke Kenyon, Chris Soentjens, Patrick van Henten, Saskia Bracke, Stefanie Vanbaelen, Thibaut Vandenhoven, Leen Bottieau, Emmanuel Vercauteren, Koen Van Esbroeck, Marjan Liesenborghs, Laurens Van Dijck, Christophe Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak |
title | Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak |
title_full | Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak |
title_fullStr | Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak |
title_full_unstemmed | Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak |
title_short | Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak |
title_sort | characteristics of confirmed mpox cases among clinical suspects: a prospective single-centre study in belgium during the 2022 outbreak |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982023/ https://www.ncbi.nlm.nih.gov/pubmed/36874154 http://dx.doi.org/10.1016/j.nmni.2023.101093 |
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