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MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics

Actin and its dynamic structural remodelings are involved in multiple cellular functions, including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle contraction. Many actin-binding proteins regulate the cytoskeleton to facilitate these functions. Recently, actin’s...

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Autores principales: Rajan, Sudeepa, Terman, Jonathan R., Reisler, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982024/
https://www.ncbi.nlm.nih.gov/pubmed/36875759
http://dx.doi.org/10.3389/fcell.2023.1124202
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author Rajan, Sudeepa
Terman, Jonathan R.
Reisler, Emil
author_facet Rajan, Sudeepa
Terman, Jonathan R.
Reisler, Emil
author_sort Rajan, Sudeepa
collection PubMed
description Actin and its dynamic structural remodelings are involved in multiple cellular functions, including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle contraction. Many actin-binding proteins regulate the cytoskeleton to facilitate these functions. Recently, actin’s post-translational modifications (PTMs) and their importance to actin functions have gained increasing recognition. The MICAL family of proteins has emerged as important actin regulatory oxidation-reduction (Redox) enzymes, influencing actin’s properties both in vitro and in vivo. MICALs specifically bind to actin filaments and selectively oxidize actin’s methionine residues 44 and 47, which perturbs filaments’ structure and leads to their disassembly. This review provides an overview of the MICALs and the impact of MICAL-mediated oxidation on actin’s properties, including its assembly and disassembly, effects on other actin-binding proteins, and on cells and tissue systems.
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spelling pubmed-99820242023-03-04 MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics Rajan, Sudeepa Terman, Jonathan R. Reisler, Emil Front Cell Dev Biol Cell and Developmental Biology Actin and its dynamic structural remodelings are involved in multiple cellular functions, including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle contraction. Many actin-binding proteins regulate the cytoskeleton to facilitate these functions. Recently, actin’s post-translational modifications (PTMs) and their importance to actin functions have gained increasing recognition. The MICAL family of proteins has emerged as important actin regulatory oxidation-reduction (Redox) enzymes, influencing actin’s properties both in vitro and in vivo. MICALs specifically bind to actin filaments and selectively oxidize actin’s methionine residues 44 and 47, which perturbs filaments’ structure and leads to their disassembly. This review provides an overview of the MICALs and the impact of MICAL-mediated oxidation on actin’s properties, including its assembly and disassembly, effects on other actin-binding proteins, and on cells and tissue systems. Frontiers Media S.A. 2023-02-17 /pmc/articles/PMC9982024/ /pubmed/36875759 http://dx.doi.org/10.3389/fcell.2023.1124202 Text en Copyright © 2023 Rajan, Terman and Reisler. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Rajan, Sudeepa
Terman, Jonathan R.
Reisler, Emil
MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics
title MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics
title_full MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics
title_fullStr MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics
title_full_unstemmed MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics
title_short MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics
title_sort mical-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982024/
https://www.ncbi.nlm.nih.gov/pubmed/36875759
http://dx.doi.org/10.3389/fcell.2023.1124202
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