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Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent
The condensation of (1H-benzimidazole-2-yl) methanamine, with 2-hydroxy naphthaldehyde lead to Schiff base ligand (H2L) (1). This was later reacted with metal salts (ZnCl(2), CrCl(3)·6H(2)O, and MnCl(2)·4H(2)O) to afford the corresponding metal complexes. Biological activity findings indicate that t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982043/ https://www.ncbi.nlm.nih.gov/pubmed/36874197 http://dx.doi.org/10.1016/j.sjbs.2023.103598 |
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author | Aroua, Lotfi M. Alhag, Sadeq K. Al-Shuraym, Laila A. Messaoudi, Sabri Mahyoub, Jazem A. Alfaifi, Mohammad Y. Al-Otaibi, Wafa Mohammed |
author_facet | Aroua, Lotfi M. Alhag, Sadeq K. Al-Shuraym, Laila A. Messaoudi, Sabri Mahyoub, Jazem A. Alfaifi, Mohammad Y. Al-Otaibi, Wafa Mohammed |
author_sort | Aroua, Lotfi M. |
collection | PubMed |
description | The condensation of (1H-benzimidazole-2-yl) methanamine, with 2-hydroxy naphthaldehyde lead to Schiff base ligand (H2L) (1). This was later reacted with metal salts (ZnCl(2), CrCl(3)·6H(2)O, and MnCl(2)·4H(2)O) to afford the corresponding metal complexes. Biological activity findings indicate that the metal complexes have promising activity against Escherichia coli and Bacillus subtilis and modest activity against Aspergillus niger. The in vitro anticancer activities of Zn (II), Cr (III), and Mn (II) complexes were investigated and the best results were observed with Mn (II) complex as the most potent cytotoxic agent toward human cell lines colorectal adenocarcinoma HCT 116, hepatocellular carcinoma HepG(2) and breast adenocarcinoma MCF-7 with 0.7, 1.1 and 6.7 μg of inhibitory concentration IC(50) values respectively. Consequently, the Mn (II) complex and ligand were docked inside the energetic site of ERK2 and exhibited favorable energy for binding. The investigation of biological tests towards mosquito larvae indicates that Cr (III) and Mn (II) complexes manifest strong toxicity against Aedes aegypti larvae with 3.458 and 4.764 ppm values of lethal concentration LC(50), respectively. |
format | Online Article Text |
id | pubmed-9982043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99820432023-03-04 Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent Aroua, Lotfi M. Alhag, Sadeq K. Al-Shuraym, Laila A. Messaoudi, Sabri Mahyoub, Jazem A. Alfaifi, Mohammad Y. Al-Otaibi, Wafa Mohammed Saudi J Biol Sci Original Article The condensation of (1H-benzimidazole-2-yl) methanamine, with 2-hydroxy naphthaldehyde lead to Schiff base ligand (H2L) (1). This was later reacted with metal salts (ZnCl(2), CrCl(3)·6H(2)O, and MnCl(2)·4H(2)O) to afford the corresponding metal complexes. Biological activity findings indicate that the metal complexes have promising activity against Escherichia coli and Bacillus subtilis and modest activity against Aspergillus niger. The in vitro anticancer activities of Zn (II), Cr (III), and Mn (II) complexes were investigated and the best results were observed with Mn (II) complex as the most potent cytotoxic agent toward human cell lines colorectal adenocarcinoma HCT 116, hepatocellular carcinoma HepG(2) and breast adenocarcinoma MCF-7 with 0.7, 1.1 and 6.7 μg of inhibitory concentration IC(50) values respectively. Consequently, the Mn (II) complex and ligand were docked inside the energetic site of ERK2 and exhibited favorable energy for binding. The investigation of biological tests towards mosquito larvae indicates that Cr (III) and Mn (II) complexes manifest strong toxicity against Aedes aegypti larvae with 3.458 and 4.764 ppm values of lethal concentration LC(50), respectively. Elsevier 2023-03 2023-02-14 /pmc/articles/PMC9982043/ /pubmed/36874197 http://dx.doi.org/10.1016/j.sjbs.2023.103598 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Aroua, Lotfi M. Alhag, Sadeq K. Al-Shuraym, Laila A. Messaoudi, Sabri Mahyoub, Jazem A. Alfaifi, Mohammad Y. Al-Otaibi, Wafa Mohammed Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent |
title | Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent |
title_full | Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent |
title_fullStr | Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent |
title_full_unstemmed | Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent |
title_short | Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent |
title_sort | synthesis and characterization of different complexes derived from schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982043/ https://www.ncbi.nlm.nih.gov/pubmed/36874197 http://dx.doi.org/10.1016/j.sjbs.2023.103598 |
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