Acute skin radiation toxicity seen with concurrent T-DM1: A single institutional report of 35 patients

Trastuzumab emtansine (T-DM1) is a novel therapeutic for HER2+ breast cancer patients with residual disease after neoadjuvant chemotherapy. Concurrent radiotherapy (RT) is offered to a subset of patients based on results from the KATHERINE trial which showed a favorable safety profile. With emerging...

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Detalles Bibliográficos
Autores principales: Dastgheyb, Sana Sara, Kim, Kristine, Doucette, Abigail, Freedman, Gary, Shah, Payal, Makhlin, Igor, Clark, Amy, Taunk, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982262/
https://www.ncbi.nlm.nih.gov/pubmed/36566691
http://dx.doi.org/10.1016/j.breast.2022.12.002
Descripción
Sumario:Trastuzumab emtansine (T-DM1) is a novel therapeutic for HER2+ breast cancer patients with residual disease after neoadjuvant chemotherapy. Concurrent radiotherapy (RT) is offered to a subset of patients based on results from the KATHERINE trial which showed a favorable safety profile. With emerging therapies that necessitate concurrent RT, we must closely follow rates of skin toxicity. Our first 35 patients who underwent concurrent T-DM1 treatment with breast/chest wall (CW) ± nodal irradiation are reported. Most patients (22/35) had grade 2+ toxicity and 3 patients had grade 3 toxicities. We add our experience with radiation dermatitis and concurrent T-DM1 to contribute to existing reports.

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