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The underused potential of breast conserving therapy after neoadjuvant system treatment – Causes and solutions
Breast conserving therapy (BCT), consisting of breast conserving surgery and subsequent radiotherapy, is an equivalent option to mastectomy for women with early breast cancer. Although BCT after neoadjuvant systemic treatment (NAST) has been routinely recommend by international guidelines since many...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982288/ https://www.ncbi.nlm.nih.gov/pubmed/36669994 http://dx.doi.org/10.1016/j.breast.2023.01.008 |
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author | Pfob, André Dubsky, Peter |
author_facet | Pfob, André Dubsky, Peter |
author_sort | Pfob, André |
collection | PubMed |
description | Breast conserving therapy (BCT), consisting of breast conserving surgery and subsequent radiotherapy, is an equivalent option to mastectomy for women with early breast cancer. Although BCT after neoadjuvant systemic treatment (NAST) has been routinely recommend by international guidelines since many years, the rate of BCT worldwide varies largely and its potential is still underused. While the rate of BCT in western countries has increased over the past decades to currently about 70%, the rate of BCT is as low as 10% in other countries. In this review, we will evaluate the underused potential of breast conservation after NAST, identify causes, and discuss possible solutions. We identified clinical and non-clinical causes for the underuse of BCT after NAST including uncertainties within the community regarding oncologic outcomes, the correct tumor localization after NAST, the management of multifocal and multicentric tumors, margin assessment, disparities of socio-economic aspects on a patient and national level, and psychological biases affecting the shared decision-making process between patients and clinicians. Possible solutions to mitigate the underuse of BCT after NAST include interdisciplinary teams that keep the whole patient pathway in mind, optimized treatment counseling and shared decision-making, and targeted financial support to alleviate disparities. |
format | Online Article Text |
id | pubmed-9982288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99822882023-03-04 The underused potential of breast conserving therapy after neoadjuvant system treatment – Causes and solutions Pfob, André Dubsky, Peter Breast Article(s) from the Special Issue on: De-escalation of loco-regional treatment; Edited by Oreste Gentilini, Philip Poortmans, Maria João Cardoso, Elzbieta Senkus-Konefka Breast conserving therapy (BCT), consisting of breast conserving surgery and subsequent radiotherapy, is an equivalent option to mastectomy for women with early breast cancer. Although BCT after neoadjuvant systemic treatment (NAST) has been routinely recommend by international guidelines since many years, the rate of BCT worldwide varies largely and its potential is still underused. While the rate of BCT in western countries has increased over the past decades to currently about 70%, the rate of BCT is as low as 10% in other countries. In this review, we will evaluate the underused potential of breast conservation after NAST, identify causes, and discuss possible solutions. We identified clinical and non-clinical causes for the underuse of BCT after NAST including uncertainties within the community regarding oncologic outcomes, the correct tumor localization after NAST, the management of multifocal and multicentric tumors, margin assessment, disparities of socio-economic aspects on a patient and national level, and psychological biases affecting the shared decision-making process between patients and clinicians. Possible solutions to mitigate the underuse of BCT after NAST include interdisciplinary teams that keep the whole patient pathway in mind, optimized treatment counseling and shared decision-making, and targeted financial support to alleviate disparities. Elsevier 2023-01-17 /pmc/articles/PMC9982288/ /pubmed/36669994 http://dx.doi.org/10.1016/j.breast.2023.01.008 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article(s) from the Special Issue on: De-escalation of loco-regional treatment; Edited by Oreste Gentilini, Philip Poortmans, Maria João Cardoso, Elzbieta Senkus-Konefka Pfob, André Dubsky, Peter The underused potential of breast conserving therapy after neoadjuvant system treatment – Causes and solutions |
title | The underused potential of breast conserving therapy after neoadjuvant system treatment – Causes and solutions |
title_full | The underused potential of breast conserving therapy after neoadjuvant system treatment – Causes and solutions |
title_fullStr | The underused potential of breast conserving therapy after neoadjuvant system treatment – Causes and solutions |
title_full_unstemmed | The underused potential of breast conserving therapy after neoadjuvant system treatment – Causes and solutions |
title_short | The underused potential of breast conserving therapy after neoadjuvant system treatment – Causes and solutions |
title_sort | underused potential of breast conserving therapy after neoadjuvant system treatment – causes and solutions |
topic | Article(s) from the Special Issue on: De-escalation of loco-regional treatment; Edited by Oreste Gentilini, Philip Poortmans, Maria João Cardoso, Elzbieta Senkus-Konefka |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982288/ https://www.ncbi.nlm.nih.gov/pubmed/36669994 http://dx.doi.org/10.1016/j.breast.2023.01.008 |
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