MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium

Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure. Mitochondrial calcium uniporter (MCU) is a key regulator for mitochondrial and cellular homeostasis. Here, Cd exposure...

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Detalles Bibliográficos
Autores principales: Liu, Cong, Li, Hui‐Juan, Duan, Wei‐Xia, Duan, Yu, Yu, Qin, Zhang, Tian, Sun, Ya‐Pei, Li, Yuan‐Yuan, Liu, Yong‐Sheng, Xu, Shang‐Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982555/
https://www.ncbi.nlm.nih.gov/pubmed/36642847
http://dx.doi.org/10.1002/advs.202203869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982555/
https://www.ncbi.nlm.nih.gov/pubmed/36642847
http://dx.doi.org/10.1002/advs.202203869

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