Cargando…

MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium

Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure. Mitochondrial calcium uniporter (MCU) is a key regulator for mitochondrial and cellular homeostasis. Here, Cd exposure...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Cong, Li, Hui‐Juan, Duan, Wei‐Xia, Duan, Yu, Yu, Qin, Zhang, Tian, Sun, Ya‐Pei, Li, Yuan‐Yuan, Liu, Yong‐Sheng, Xu, Shang‐Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982555/ https://www.ncbi.nlm.nih.gov/pubmed/36642847 http://dx.doi.org/10.1002/advs.202203869

Ejemplares similares

Taurine Alleviates Cadmium-Induced Hepatotoxicity by Regulating Autophagy Flux
por: Duan, Yuntian, et al.
Publicado: (2023)

MCU Up‐regulation contributes to myocardial ischemia‐reperfusion Injury through calpain/OPA‐1–mediated mitochondrial fusion/mitophagy Inhibition
por: Guan, Lichun, et al.
Publicado: (2019)

ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS
por: Magrì, Andrea, et al.
Publicado: (2023)

IP(3)R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model
por: Xu, Han, et al.
Publicado: (2018)

Noncovalent Dimerization of Ubiquitin**
por: Liu, Zhu, et al.
Publicado: (2012)

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin
por: Pi, Huifeng, et al.
Publicado: (2015)

Stellate Ganglia and Cardiac Sympathetic Overactivation in Heart Failure
por: Li, Yu-Long
Publicado: (2022)

Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy
por: Baulies, Anna, et al.
Publicado: (2015)

Salidroside Protects against Cadmium-Induced Hepatotoxicity in Rats via GJIC and MAPK Pathways
por: Zou, Hui, et al.
Publicado: (2015)

Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane
por: Bondarenko, Alexander I., et al.
Publicado: (2013)

Pyk2/MCU Pathway as a New Target for Reversing Atherosclerosis
por: Zhang, Yingzhen, et al.
Publicado: (2021)

Upregulation of the ERRγ–VDAC1 axis underlies the molecular pathogenesis of pancreatitis
por: Chanda, Dipanjan, et al.
Publicado: (2023)

Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy
por: Yi, Lingna, et al.
Publicado: (2022)

Overactivated neddylation pathway in human hepatocellular carcinoma
por: Yu, Jian, et al.
Publicado: (2018)

MCU knockdown in hippocampal neurons improves memory performance of an Alzheimer’s disease mouse model : MCU knockdown improves memory performance
por: Cai, Hongyan, et al.
Publicado: (2022)

Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure
por: Zhang, Dongze, et al.
Publicado: (2021)

A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model
por: Vijayan, Murali, et al.
Publicado: (2022)

The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy
por: Sun, Shan, et al.
Publicado: (2022)

Structure of intact human MCU supercomplex with the auxiliary MICU subunits
por: Zhuo, Wei, et al.
Publicado: (2020)

Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases
por: Niture, Suryakant, et al.
Publicado: (2021)

Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia
por: Zhu, Ting, et al.
Publicado: (2021)

Mitophagy is induced by short ubiquitin chains on mitochondria
por: Ikeda, Fumiyo
Publicado: (2020)

Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1
por: May, Olivia, et al.
Publicado: (2018)

Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells
por: Watanabe, Akira, et al.
Publicado: (2022)

C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement Overactivation
por: Li, Hai-Yun, et al.
Publicado: (2021)

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
por: Guo, Pan, et al.
Publicado: (2014)

CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells
por: Li, Qin-qin, et al.
Publicado: (2015)

VDAC2 and the BCL-2 family of proteins
por: Yuan, Zheng, et al.
Publicado: (2021)

The Effect of Multiwalled Carbon Nanotubes on Hepatotoxicity of Cd(2+) in Accumulated Cadmium-Metallothione in Mice
por: Wei, Qi, et al.
Publicado: (2014)

Irradiation Measurements of the Hitachi H8S/2357 MCU
por: Navarrete, J J, et al.
Publicado: (2003)

MCU encodes the pore conducting mitochondrial calcium currents
por: Chaudhuri, Dipayan, et al.
Publicado: (2013)

Overactivation of histone deacetylases and EZH2 in Wilms tumorigenesis
por: Chen, Chao-Hui, et al.
Publicado: (2022)

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis
por: Gui, Yao-Song, et al.
Publicado: (2015)

Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death
por: Liao, Yajin, et al.
Publicado: (2015)

The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation
por: Zhu, Yiwei, et al.
Publicado: (2023)

Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis
por: Wu, Ne N., et al.
Publicado: (2023)

VDAC1 Negatively Regulates Floral Transition in Arabidopsis thaliana
por: Xu, Jingya, et al.
Publicado: (2021)

Overexpression of a Voltage-Dependent Anion-Selective Channel (VDAC) Protein-Encoding Gene, MsVDAC, from Medicago sativa Confers Cold and Drought Tolerance to Transgenic Tobacco
por: Yang, Mei, et al.
Publicado: (2021)

Downregulated miR-29a promotes B cell overactivation by upregulating Crk-like protein in systemic lupus erythematosus
por: Shi, Xinyu, et al.
Publicado: (2020)

Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy
por: Mann, Guy, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8u9pf7j7i4rpk0pa2ac3c2coqt