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MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium
Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure. Mitochondrial calcium uniporter (MCU) is a key regulator for mitochondrial and cellular homeostasis. Here, Cd exposure...
Autores principales: | Liu, Cong, Li, Hui‐Juan, Duan, Wei‐Xia, Duan, Yu, Yu, Qin, Zhang, Tian, Sun, Ya‐Pei, Li, Yuan‐Yuan, Liu, Yong‐Sheng, Xu, Shang‐Cheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982555/ https://www.ncbi.nlm.nih.gov/pubmed/36642847 http://dx.doi.org/10.1002/advs.202203869 |
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