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Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel

Continuous monitoring of glucose allows diabetic patients to better maintain blood glucose level by altering insulin dosage or diet according to prevailing glucose values and thus to prevent potential hyperglycemia and hypoglycemia. However, current continuous glucose monitoring (CGM) relies mostly...

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Autores principales: Zhang, Jian, Zheng, Yongjun, Lee, Jimmy, Hoover, Alex, King, Sarah Ann, Chen, Lifeng, Zhao, Jing, Lin, Qiuning, Yu, Cunjiang, Zhu, Linyong, Wu, Xiaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982560/
https://www.ncbi.nlm.nih.gov/pubmed/36646501
http://dx.doi.org/10.1002/advs.202203943
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author Zhang, Jian
Zheng, Yongjun
Lee, Jimmy
Hoover, Alex
King, Sarah Ann
Chen, Lifeng
Zhao, Jing
Lin, Qiuning
Yu, Cunjiang
Zhu, Linyong
Wu, Xiaoyang
author_facet Zhang, Jian
Zheng, Yongjun
Lee, Jimmy
Hoover, Alex
King, Sarah Ann
Chen, Lifeng
Zhao, Jing
Lin, Qiuning
Yu, Cunjiang
Zhu, Linyong
Wu, Xiaoyang
author_sort Zhang, Jian
collection PubMed
description Continuous monitoring of glucose allows diabetic patients to better maintain blood glucose level by altering insulin dosage or diet according to prevailing glucose values and thus to prevent potential hyperglycemia and hypoglycemia. However, current continuous glucose monitoring (CGM) relies mostly on enzyme electrodes or micro‐dialysis probes, which suffer from insufficient stability, susceptibility to corrosion of electrodes, weak or inconsistent correlation, and inevitable interference. A fluorescence‐based glucose sensor in the skin will likely be more stable, have improved sensitivity, and can resolve the issues of electrochemical interference from the tissue. This study develops a fluorescent nanodiamond boronic hydrogel system in porous microneedles for CGM. Fluorescent nanodiamond is one of the most photostable fluorophores with superior biocompatibility. When surface functionalized, the fluorescent nanodiamond can integrate with boronic polymer and form a hydrogel, which can produce fluorescent signals in response to environmental glucose concentration. In this proof‐of‐concept study, the strategy for building a miniatured device with fluorescent nanodiamond hydrogel is developed. The device demonstrates remarkable long‐term photo and signal stability in vivo with both small and large animal models. This study presents a new strategy of fluorescence based CGM toward treatment and control of diabetes.
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spelling pubmed-99825602023-03-04 Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel Zhang, Jian Zheng, Yongjun Lee, Jimmy Hoover, Alex King, Sarah Ann Chen, Lifeng Zhao, Jing Lin, Qiuning Yu, Cunjiang Zhu, Linyong Wu, Xiaoyang Adv Sci (Weinh) Research Articles Continuous monitoring of glucose allows diabetic patients to better maintain blood glucose level by altering insulin dosage or diet according to prevailing glucose values and thus to prevent potential hyperglycemia and hypoglycemia. However, current continuous glucose monitoring (CGM) relies mostly on enzyme electrodes or micro‐dialysis probes, which suffer from insufficient stability, susceptibility to corrosion of electrodes, weak or inconsistent correlation, and inevitable interference. A fluorescence‐based glucose sensor in the skin will likely be more stable, have improved sensitivity, and can resolve the issues of electrochemical interference from the tissue. This study develops a fluorescent nanodiamond boronic hydrogel system in porous microneedles for CGM. Fluorescent nanodiamond is one of the most photostable fluorophores with superior biocompatibility. When surface functionalized, the fluorescent nanodiamond can integrate with boronic polymer and form a hydrogel, which can produce fluorescent signals in response to environmental glucose concentration. In this proof‐of‐concept study, the strategy for building a miniatured device with fluorescent nanodiamond hydrogel is developed. The device demonstrates remarkable long‐term photo and signal stability in vivo with both small and large animal models. This study presents a new strategy of fluorescence based CGM toward treatment and control of diabetes. John Wiley and Sons Inc. 2023-01-16 /pmc/articles/PMC9982560/ /pubmed/36646501 http://dx.doi.org/10.1002/advs.202203943 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Zhang, Jian
Zheng, Yongjun
Lee, Jimmy
Hoover, Alex
King, Sarah Ann
Chen, Lifeng
Zhao, Jing
Lin, Qiuning
Yu, Cunjiang
Zhu, Linyong
Wu, Xiaoyang
Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel
title Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel
title_full Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel
title_fullStr Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel
title_full_unstemmed Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel
title_short Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel
title_sort continuous glucose monitoring enabled by fluorescent nanodiamond boronic hydrogel
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982560/
https://www.ncbi.nlm.nih.gov/pubmed/36646501
http://dx.doi.org/10.1002/advs.202203943
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