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Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment

Dysregulated epigenetic modifications dynamically drive the abnormal transcription process to affect the tumor microenvironment; thus, promoting cancer progression, drug resistance, and metastasis. Nowadays, therapies targeting epigenetic dysregulation of tumor cells and immune cells in the tumor mi...

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Detalles Bibliográficos
Autores principales: Zhang, Jiaxin, Huang, Leaf, Ge, Guangbo, Hu, Kaili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982594/
https://www.ncbi.nlm.nih.gov/pubmed/36599655
http://dx.doi.org/10.1002/advs.202206169
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author Zhang, Jiaxin
Huang, Leaf
Ge, Guangbo
Hu, Kaili
author_facet Zhang, Jiaxin
Huang, Leaf
Ge, Guangbo
Hu, Kaili
author_sort Zhang, Jiaxin
collection PubMed
description Dysregulated epigenetic modifications dynamically drive the abnormal transcription process to affect the tumor microenvironment; thus, promoting cancer progression, drug resistance, and metastasis. Nowadays, therapies targeting epigenetic dysregulation of tumor cells and immune cells in the tumor microenvironment appear to be promising adjuncts to other cancer therapies. However, the clinical results of combination therapies containing epigenetic agents are disappointing due to systemic toxicities and limited curative effects. Here, the role of epigenetic processes, including DNA methylation, post‐translational modification of histones, and noncoding RNAs is discussed, followed by detailed descriptions of epigenetic regulation of the tumor microenvironment, as well as the application of epigenetic modulators in antitumor therapy, with an emphasis on the epigenetic‐based advanced drug delivery system in targeting the tumor microenvironment.
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spelling pubmed-99825942023-03-04 Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment Zhang, Jiaxin Huang, Leaf Ge, Guangbo Hu, Kaili Adv Sci (Weinh) Reviews Dysregulated epigenetic modifications dynamically drive the abnormal transcription process to affect the tumor microenvironment; thus, promoting cancer progression, drug resistance, and metastasis. Nowadays, therapies targeting epigenetic dysregulation of tumor cells and immune cells in the tumor microenvironment appear to be promising adjuncts to other cancer therapies. However, the clinical results of combination therapies containing epigenetic agents are disappointing due to systemic toxicities and limited curative effects. Here, the role of epigenetic processes, including DNA methylation, post‐translational modification of histones, and noncoding RNAs is discussed, followed by detailed descriptions of epigenetic regulation of the tumor microenvironment, as well as the application of epigenetic modulators in antitumor therapy, with an emphasis on the epigenetic‐based advanced drug delivery system in targeting the tumor microenvironment. John Wiley and Sons Inc. 2023-01-04 /pmc/articles/PMC9982594/ /pubmed/36599655 http://dx.doi.org/10.1002/advs.202206169 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Zhang, Jiaxin
Huang, Leaf
Ge, Guangbo
Hu, Kaili
Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment
title Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment
title_full Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment
title_fullStr Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment
title_full_unstemmed Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment
title_short Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment
title_sort emerging epigenetic‐based nanotechnology for cancer therapy: modulating the tumor microenvironment
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982594/
https://www.ncbi.nlm.nih.gov/pubmed/36599655
http://dx.doi.org/10.1002/advs.202206169
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