Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia

OBJECTIVE: To evaluate risk factors for neuropsychiatric disorders (NPD) in recipients of CART therapy. METHODS: Patients ≥ 18 years with acute lymphoblastic leukemia (ALL), and aggressive B-cell lymphomas who received CART in 2018 were evaluated. Patients with and without NPD were compared. RESULTS...

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Autores principales: Emole, Josephine, Lawal, Odunayo, Lupak, Oleksandra, Rangarajan, Hemalatha, Udo, Itoro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982636/
https://www.ncbi.nlm.nih.gov/pubmed/36873581
http://dx.doi.org/10.1016/j.lrr.2023.100364
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author Emole, Josephine
Lawal, Odunayo
Lupak, Oleksandra
Rangarajan, Hemalatha
Udo, Itoro
author_facet Emole, Josephine
Lawal, Odunayo
Lupak, Oleksandra
Rangarajan, Hemalatha
Udo, Itoro
author_sort Emole, Josephine
collection PubMed
description OBJECTIVE: To evaluate risk factors for neuropsychiatric disorders (NPD) in recipients of CART therapy. METHODS: Patients ≥ 18 years with acute lymphoblastic leukemia (ALL), and aggressive B-cell lymphomas who received CART in 2018 were evaluated. Patients with and without NPD were compared. RESULTS: NPD was diagnosed in 31.2% of patients. Compared to patients without NPD, patients with NPD were likely to be females (P = 0.035) and have ALL (P = 0.039). NPD was significantly associated with female gender (OR = 2.03) and diagnosis of ALL (OR = 2.76). No association between NPD and outcomes. CONCLUSIONS: Female gender and ALL were risk factors for NPD.
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spelling pubmed-99826362023-03-04 Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia Emole, Josephine Lawal, Odunayo Lupak, Oleksandra Rangarajan, Hemalatha Udo, Itoro Leuk Res Rep Article OBJECTIVE: To evaluate risk factors for neuropsychiatric disorders (NPD) in recipients of CART therapy. METHODS: Patients ≥ 18 years with acute lymphoblastic leukemia (ALL), and aggressive B-cell lymphomas who received CART in 2018 were evaluated. Patients with and without NPD were compared. RESULTS: NPD was diagnosed in 31.2% of patients. Compared to patients without NPD, patients with NPD were likely to be females (P = 0.035) and have ALL (P = 0.039). NPD was significantly associated with female gender (OR = 2.03) and diagnosis of ALL (OR = 2.76). No association between NPD and outcomes. CONCLUSIONS: Female gender and ALL were risk factors for NPD. Elsevier 2023-02-17 /pmc/articles/PMC9982636/ /pubmed/36873581 http://dx.doi.org/10.1016/j.lrr.2023.100364 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Emole, Josephine
Lawal, Odunayo
Lupak, Oleksandra
Rangarajan, Hemalatha
Udo, Itoro
Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
title Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
title_full Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
title_fullStr Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
title_full_unstemmed Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
title_short Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
title_sort neuropsychiatric disorders in adults undergoing chimeric antigen receptor t cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982636/
https://www.ncbi.nlm.nih.gov/pubmed/36873581
http://dx.doi.org/10.1016/j.lrr.2023.100364
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