Indirect bilirubin impairs invasion of osteosarcoma cells via inhibiting the PI3K/AKT/MMP-2 signaling pathway by suppressing intracellular ROS

BACKGROUND: Osteosarcoma is most prevalently found primary malignant bone tumors, with primary metastatic patients accounting for approximately 25% of all osteosarcoma patients, yet their 5-year OS remains below 30%. Bilirubin plays a key role in oxidative stress-associated events, including maligna...

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Detalles Bibliográficos
Autores principales: Yuan, Xuhui, Ma, Cong, Li, Jiayu, Li, Junhong, Yu, Ronghui, Cai, Feng, Qu, Gaoyang, Yu, Bo, Liu, Lang, Zeng, Duo, Jiao, QuanHui, Liao, Qi, Lv, Xiaobin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982672/
https://www.ncbi.nlm.nih.gov/pubmed/36876225
http://dx.doi.org/10.1016/j.jbo.2023.100472

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