Cargando…

Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model

BACKGROUND: As of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations regarding the management of biliary strictures caused by intrahe...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, In Rae, Lee, Sang Hyub, Choi, Jin Ho, Park, Namyoung, Lee, Min Woo, Kim, Joo Seong, Jeong, Seok, Lee, Don Haeng, Jeong, Tae-Won, Ki, Byoung-Yun, Paik, Woo Hyun, Ryu, Ji Kon, Kim, Yong-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982730/
https://www.ncbi.nlm.nih.gov/pubmed/36874108
http://dx.doi.org/10.3389/fonc.2023.1103217
_version_ 1784900389873647616
author Cho, In Rae
Lee, Sang Hyub
Choi, Jin Ho
Park, Namyoung
Lee, Min Woo
Kim, Joo Seong
Jeong, Seok
Lee, Don Haeng
Jeong, Tae-Won
Ki, Byoung-Yun
Paik, Woo Hyun
Ryu, Ji Kon
Kim, Yong-Tae
author_facet Cho, In Rae
Lee, Sang Hyub
Choi, Jin Ho
Park, Namyoung
Lee, Min Woo
Kim, Joo Seong
Jeong, Seok
Lee, Don Haeng
Jeong, Tae-Won
Ki, Byoung-Yun
Paik, Woo Hyun
Ryu, Ji Kon
Kim, Yong-Tae
author_sort Cho, In Rae
collection PubMed
description BACKGROUND: As of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations regarding the management of biliary strictures caused by intrahepatic and hilar cholangiocarcinoma. PS has short patency and also risks bile duct injury and bowel perforation. SEMS is difficult to revise when occluded by tumor overgrowth. To compensate for such shortcomings, we developed a novel biliary metal stent with coil-spring structure. The aim of this study was to investigate the feasibility and efficacy of the novel stent in a swine model. METHODS: The biliary stricture model was prepared in six mini-pigs using endobiliary radiofrequency ablation. Conventional PS (n=2) and novel stents (n=4) were deployed endoscopically. Technical success was defined as successful stent placement and clinical success was defined as >50% reduction of serum bilirubin level. Adverse events, stent migration, and endoscopic removability for one month after stenting were also assessed. RESULTS: The biliary stricture was successfully created in all animals. The technical success rate was 100 %, and the clinical success rate was 50% in the PS group and 75% in the novel stent group. In the novel stent group, the median pre- and post-treatment serum bilirubin levels were 3.94 and 0.3 mg/dL. Stent migration occurred in two pigs and two stents were removed by endoscopy. There was no stent-related mortality. CONCLUSIONS: The newly designed biliary metal stent was feasible and effective in a swine biliary stricture model. Further studies are needed to verify the usefulness of the novel stent in the management of biliary strictures.
format Online
Article
Text
id pubmed-9982730
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-99827302023-03-04 Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model Cho, In Rae Lee, Sang Hyub Choi, Jin Ho Park, Namyoung Lee, Min Woo Kim, Joo Seong Jeong, Seok Lee, Don Haeng Jeong, Tae-Won Ki, Byoung-Yun Paik, Woo Hyun Ryu, Ji Kon Kim, Yong-Tae Front Oncol Oncology BACKGROUND: As of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations regarding the management of biliary strictures caused by intrahepatic and hilar cholangiocarcinoma. PS has short patency and also risks bile duct injury and bowel perforation. SEMS is difficult to revise when occluded by tumor overgrowth. To compensate for such shortcomings, we developed a novel biliary metal stent with coil-spring structure. The aim of this study was to investigate the feasibility and efficacy of the novel stent in a swine model. METHODS: The biliary stricture model was prepared in six mini-pigs using endobiliary radiofrequency ablation. Conventional PS (n=2) and novel stents (n=4) were deployed endoscopically. Technical success was defined as successful stent placement and clinical success was defined as >50% reduction of serum bilirubin level. Adverse events, stent migration, and endoscopic removability for one month after stenting were also assessed. RESULTS: The biliary stricture was successfully created in all animals. The technical success rate was 100 %, and the clinical success rate was 50% in the PS group and 75% in the novel stent group. In the novel stent group, the median pre- and post-treatment serum bilirubin levels were 3.94 and 0.3 mg/dL. Stent migration occurred in two pigs and two stents were removed by endoscopy. There was no stent-related mortality. CONCLUSIONS: The newly designed biliary metal stent was feasible and effective in a swine biliary stricture model. Further studies are needed to verify the usefulness of the novel stent in the management of biliary strictures. Frontiers Media S.A. 2023-02-13 /pmc/articles/PMC9982730/ /pubmed/36874108 http://dx.doi.org/10.3389/fonc.2023.1103217 Text en Copyright © 2023 Cho, Lee, Choi, Park, Lee, Kim, Jeong, Lee, Jeong, Ki, Paik, Ryu and Kim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cho, In Rae
Lee, Sang Hyub
Choi, Jin Ho
Park, Namyoung
Lee, Min Woo
Kim, Joo Seong
Jeong, Seok
Lee, Don Haeng
Jeong, Tae-Won
Ki, Byoung-Yun
Paik, Woo Hyun
Ryu, Ji Kon
Kim, Yong-Tae
Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
title Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
title_full Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
title_fullStr Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
title_full_unstemmed Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
title_short Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
title_sort development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982730/
https://www.ncbi.nlm.nih.gov/pubmed/36874108
http://dx.doi.org/10.3389/fonc.2023.1103217
work_keys_str_mv AT choinrae developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT leesanghyub developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT choijinho developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT parknamyoung developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT leeminwoo developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT kimjooseong developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT jeongseok developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT leedonhaeng developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT jeongtaewon developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT kibyoungyun developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT paikwoohyun developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT ryujikon developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel
AT kimyongtae developmentofnovelbiliarymetalstentwithcoilspringstructureanditsapplicationinvivoswinebiliarystricturemodel