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Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
BACKGROUND: As of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations regarding the management of biliary strictures caused by intrahe...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982730/ https://www.ncbi.nlm.nih.gov/pubmed/36874108 http://dx.doi.org/10.3389/fonc.2023.1103217 |
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author | Cho, In Rae Lee, Sang Hyub Choi, Jin Ho Park, Namyoung Lee, Min Woo Kim, Joo Seong Jeong, Seok Lee, Don Haeng Jeong, Tae-Won Ki, Byoung-Yun Paik, Woo Hyun Ryu, Ji Kon Kim, Yong-Tae |
author_facet | Cho, In Rae Lee, Sang Hyub Choi, Jin Ho Park, Namyoung Lee, Min Woo Kim, Joo Seong Jeong, Seok Lee, Don Haeng Jeong, Tae-Won Ki, Byoung-Yun Paik, Woo Hyun Ryu, Ji Kon Kim, Yong-Tae |
author_sort | Cho, In Rae |
collection | PubMed |
description | BACKGROUND: As of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations regarding the management of biliary strictures caused by intrahepatic and hilar cholangiocarcinoma. PS has short patency and also risks bile duct injury and bowel perforation. SEMS is difficult to revise when occluded by tumor overgrowth. To compensate for such shortcomings, we developed a novel biliary metal stent with coil-spring structure. The aim of this study was to investigate the feasibility and efficacy of the novel stent in a swine model. METHODS: The biliary stricture model was prepared in six mini-pigs using endobiliary radiofrequency ablation. Conventional PS (n=2) and novel stents (n=4) were deployed endoscopically. Technical success was defined as successful stent placement and clinical success was defined as >50% reduction of serum bilirubin level. Adverse events, stent migration, and endoscopic removability for one month after stenting were also assessed. RESULTS: The biliary stricture was successfully created in all animals. The technical success rate was 100 %, and the clinical success rate was 50% in the PS group and 75% in the novel stent group. In the novel stent group, the median pre- and post-treatment serum bilirubin levels were 3.94 and 0.3 mg/dL. Stent migration occurred in two pigs and two stents were removed by endoscopy. There was no stent-related mortality. CONCLUSIONS: The newly designed biliary metal stent was feasible and effective in a swine biliary stricture model. Further studies are needed to verify the usefulness of the novel stent in the management of biliary strictures. |
format | Online Article Text |
id | pubmed-9982730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99827302023-03-04 Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model Cho, In Rae Lee, Sang Hyub Choi, Jin Ho Park, Namyoung Lee, Min Woo Kim, Joo Seong Jeong, Seok Lee, Don Haeng Jeong, Tae-Won Ki, Byoung-Yun Paik, Woo Hyun Ryu, Ji Kon Kim, Yong-Tae Front Oncol Oncology BACKGROUND: As of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations regarding the management of biliary strictures caused by intrahepatic and hilar cholangiocarcinoma. PS has short patency and also risks bile duct injury and bowel perforation. SEMS is difficult to revise when occluded by tumor overgrowth. To compensate for such shortcomings, we developed a novel biliary metal stent with coil-spring structure. The aim of this study was to investigate the feasibility and efficacy of the novel stent in a swine model. METHODS: The biliary stricture model was prepared in six mini-pigs using endobiliary radiofrequency ablation. Conventional PS (n=2) and novel stents (n=4) were deployed endoscopically. Technical success was defined as successful stent placement and clinical success was defined as >50% reduction of serum bilirubin level. Adverse events, stent migration, and endoscopic removability for one month after stenting were also assessed. RESULTS: The biliary stricture was successfully created in all animals. The technical success rate was 100 %, and the clinical success rate was 50% in the PS group and 75% in the novel stent group. In the novel stent group, the median pre- and post-treatment serum bilirubin levels were 3.94 and 0.3 mg/dL. Stent migration occurred in two pigs and two stents were removed by endoscopy. There was no stent-related mortality. CONCLUSIONS: The newly designed biliary metal stent was feasible and effective in a swine biliary stricture model. Further studies are needed to verify the usefulness of the novel stent in the management of biliary strictures. Frontiers Media S.A. 2023-02-13 /pmc/articles/PMC9982730/ /pubmed/36874108 http://dx.doi.org/10.3389/fonc.2023.1103217 Text en Copyright © 2023 Cho, Lee, Choi, Park, Lee, Kim, Jeong, Lee, Jeong, Ki, Paik, Ryu and Kim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Cho, In Rae Lee, Sang Hyub Choi, Jin Ho Park, Namyoung Lee, Min Woo Kim, Joo Seong Jeong, Seok Lee, Don Haeng Jeong, Tae-Won Ki, Byoung-Yun Paik, Woo Hyun Ryu, Ji Kon Kim, Yong-Tae Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
title | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
title_full | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
title_fullStr | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
title_full_unstemmed | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
title_short | Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
title_sort | development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982730/ https://www.ncbi.nlm.nih.gov/pubmed/36874108 http://dx.doi.org/10.3389/fonc.2023.1103217 |
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